A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis
Yoon, Sung-Hee, Meyer, Mark B, Arevalo, Carlos, Tekguc, Murat, Zhang, Chengcheng, Wang, Jialiang S, Castro Andrade, Christian D, Strauss, Katelyn, Sato, Tadatoshi, Benkusky, Nancy A, Lee, Seong Min, Berdeaux, Rebecca, Foretz, Marc, Sundberg, Thomas B, Xavier, Ramnik J, Adelmann, Charles H, Brooks, Daniel J, Anselmo, Anthony, Sadreyev, Ruslan I, Rosales, Ivy A, Fisher, David E, Gupta, Navin, Morizane, Ryuji, Greka, Anna, Pike, J Wesley, Mannstadt, Michael, Wein, Marc N
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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging
Gustafson, Jeffrey L., Neklesa, Taavi K., Cox, Carly S., Roth, Anke G., Buckley, Dennis L., Tae, Hyun Seop, Sundberg, Thomas B., Stagg, D. Blake, Hines, John, McDonnell, Donald P., Norris, John D., Crews, Craig M.
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Published in Angewandte Chemie (International ed.) (10.08.2015)
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Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins
Neklesa, Taavi K, Tae, Hyun Seop, Schneekloth, Ashley R, Stulberg, Michael J, Corson, Timothy W, Sundberg, Thomas B, Raina, Kanak, Holley, Scott A, Crews, Craig M
Published in Nature chemical biology (03.07.2011)
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SIKs control osteocyte responses to parathyroid hormone
Wein, Marc N., Liang, Yanke, Goransson, Olga, Sundberg, Thomas B., Wang, Jinhua, Williams, Elizabeth A., O’Meara, Maureen J., Govea, Nicolas, Beqo, Belinda, Nishimori, Shigeki, Nagano, Kenichi, Brooks, Daniel J., Martins, Janaina S., Corbin, Braden, Anselmo, Anthony, Sadreyev, Ruslan, Wu, Joy Y., Sakamoto, Kei, Foretz, Marc, Xavier, Ramnik J., Baron, Roland, Bouxsein, Mary L., Gardella, Thomas J., Divieti-Pajevic, Paola, Gray, Nathanael S., Kronenberg, Henry M.
Published in Nature communications (19.10.2016)
Published in Nature communications (19.10.2016)
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Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease
Gatza, Erin, Wahl, Daniel R, Opipari, Anthony W, Sundberg, Thomas B, Reddy, Pavan, Liu, Chen, Glick, Gary D, Ferrara, James L M
Published in Science translational medicine (26.01.2011)
Published in Science translational medicine (26.01.2011)
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
Sundberg, Thomas B., Choi, Hwan Geun, Song, Joo-Hye, Russell, Caitlin N., Hussain, Mahmud M., Graham, Daniel B., Khor, Bernard, Gagnon, John, O'Connell, Daniel J., Narayan, Kavitha, Dančik, Vlado, Perez, Jose R., Reinecker, Hans-Christian, Gray, Nathanael S., Schreiber, Stuart L., Xavier, Ramnik J., Shamji, Alykhan F.
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
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Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo
Sundberg, Thomas B, Liang, Yanke, Wu, Huixian, Choi, Hwan Geun, Kim, Nam Doo, Sim, Taebo, Johannessen, Liv, Petrone, Adam, Khor, Bernard, Graham, Daniel B, Latorre, Isabel J, Phillips, Andrew J, Schreiber, Stuart L, Perez, Jose, Shamji, Alykhan F, Gray, Nathanael S, Xavier, Ramnik J
Published in ACS chemical biology (19.08.2016)
Published in ACS chemical biology (19.08.2016)
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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Babbe, Holger, Sundberg, Thomas B, Tichenor, Mark, Seierstad, Mark, Bacani, Genesis, Berstler, James, Chai, Wenying, Chang, Leon, Chung, De Michael, Coe, Kevin, Collins, Bernard, Finley, Michael, Guletsky, Alexander, Lemke, Christopher T, Mak, Puiying A, Mathur, Ashok, Mercado-Marin, Eduardo V, Metkar, Shailesh, Raymond, Donald D, Rives, Marie-Laure, Rizzolio, Michele, Shaffer, Paul L, Smith, Russell, Smith, Jacqueline, Steele, Ruth, Steffens, Helena, Suarez, Javier, Tian, Gaochao, Majewski, Nathan, Volak, Laurie P, Wei, Jianmei, Desai, Prerak T, Ong, Luvena L, Koudriakova, Tatiana, Goldberg, Steven D, Hirst, Gavin, Kaushik, Virendar K, Ort, Tatiana, Seth, Nilufer, Graham, Daniel B, Plevy, Scott, Venable, Jennifer D, Xavier, Ramnik J, Towne, Jennifer E
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
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Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells
Johannessen, Liv, Sundberg, Thomas B, O'Connell, Daniel J, Kolde, Raivo, Berstler, James, Billings, Katelyn J, Khor, Bernard, Seashore-Ludlow, Brinton, Fassl, Anne, Russell, Caitlin N, Latorre, Isabel J, Jiang, Baishan, Graham, Daniel B, Perez, Jose R, Sicinski, Piotr, Phillips, Andrew J, Schreiber, Stuart L, Gray, Nathanael S, Shamji, Alykhan F, Xavier, Ramnik J
Published in Nature chemical biology (01.10.2017)
Published in Nature chemical biology (01.10.2017)
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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
Tang, Cheng-Chia, Castro Andrade, Christian D, O'Meara, Maureen J, Yoon, Sung-Hee, Sato, Tadatoshi, Brooks, Daniel J, Bouxsein, Mary L, Martins, Janaina da Silva, Wang, Jinhua, Gray, Nathanael S, Misof, Barbara, Roschger, Paul, Blouin, Stephane, Klaushofer, Klaus, Velduis-Vlug, Annegreet, Vegting, Yosta, Rosen, Clifford J, O'Connell, Daniel, Sundberg, Thomas B, Xavier, Ramnik J, Ung, Peter, Schlessinger, Avner, Kronenberg, Henry M, Berdeaux, Rebecca, Foretz, Marc, Wein, Marc N
Published in eLife (23.06.2021)
Published in eLife (23.06.2021)
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The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway
Arnett, Azlann, Moo, Keagan G., Flynn, Kaitlin J., Sundberg, Thomas B., Johannessen, Liv, Shamji, Alykhan F., Gray, Nathanael S., Decker, Thomas, Zheng, Ye, Gersuk, Vivian H., Rahman, Ziaur S., Levy, David E., Marié, Isabelle J., Linsley, Peter S., Xavier, Ramnik J., Khor, Bernard
Published in Molecular and cellular biology (24.08.2021)
Published in Molecular and cellular biology (24.08.2021)
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Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins
Tae, Hyun Seop, Sundberg, Thomas B., Neklesa, Taavi K., Noblin, Devin J., Gustafson, Jeffrey L., Roth, Anke G., Raina, Kanak, Crews, Craig M.
Published in Chembiochem : a European journal of chemical biology (05.03.2012)
Published in Chembiochem : a European journal of chemical biology (05.03.2012)
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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
Khor, Bernard, Gagnon, John D, Goel, Gautam, Roche, Marly I, Conway, Kara L, Tran, Khoa, Aldrich, Leslie N, Sundberg, Thomas B, Paterson, Alison M, Mordecai, Scott, Dombkowski, David, Schirmer, Melanie, Tan, Pauline H, Bhan, Atul K, Roychoudhuri, Rahul, Restifo, Nicholas P, O'Shea, John J, Medoff, Benjamin D, Shamji, Alykhan F, Schreiber, Stuart L, Sharpe, Arlene H, Shaw, Stanley Y, Xavier, Ramnik J
Published in eLife (22.05.2015)
Published in eLife (22.05.2015)
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Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing
O’Connell, Daniel J., Kolde, Raivo, Sooknah, Matthew, Graham, Daniel B., Sundberg, Thomas B., Latorre, Isabel J., Mikkelsen, Tarjei S., Xavier, Ramnik J.
Published in Cell systems (25.05.2016)
Published in Cell systems (25.05.2016)
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Apoptotic Signaling Activated by Modulation of the F0F1-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes
Sundberg, Thomas B, Swenson, Lara, Wahl, Daniel R, Opipari, Jr, Anthony W, Glick, Gary D
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
Bhagavathula, Narasimharao, Nerusu, Kamalakar C, Hanosh, Andrew, Aslam, Muhammad N, Sundberg, Thomas B, Opipari, Jr, Anthony W, Johnson, Kent, Kang, Sewon, Glick, Gary D, Varani, James
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation
SUNDBERG, Thomas B, NEY, Gina M, SUBRAMANIAN, Chitra, OPIPARI, Anthony W, GLICK, Gary D
Published in Cancer research (Chicago, Ill.) (01.02.2006)
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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Disruption of Wnt Planar Cell Polarity Signaling by Aberrant Accumulation of the MetAP-2 Substrate Rab37
Sundberg, Thomas B., Darricarrere, Nicole, Cirone, Pasquale, Li, Xia, McDonald, Lucy, Mei, Xue, Westlake, Christopher J., Slusarski, Diane C., Beynon, Robert J., Crews, Craig M.
Published in Chemistry & biology (28.10.2011)
Published in Chemistry & biology (28.10.2011)
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