Search Results - "PAUL D. VAN POELJE" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

by Erion, Mark D, Cable, Edward E, Ito, Bruce R, Jiang, Hongjian, Fujitaki, James M, Finn, Patricia D, Zhang, Bao-Hong, Hou, Jinzhao, Boyer, Serge H, van Poelje, Paul D, Linemeyer, David L
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2007)

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Fructose-1,6-bisphosphatase Inhibitors. 1. Purine Phosphonic Acids as Novel AMP Mimics

Fructose-1,6-bisphosphatase Inhibitors. 1. Purine Phosphonic Acids as Novel AMP Mimics

by Dang, Qun, Brown, Brian S, Liu, Yan, Rydzewski, Robert M, Robinson, Edward D, Poelje, Paul D. van, Reddy, M. Rami, Erion, Mark D
Published in Journal of medicinal chemistry (14.05.2009)

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Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes

Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes

by Dang, Qun, Kasibhatla, Srinivas Rao, Reddy, K. Raja, Jiang, Tao, Reddy, M. Rami, Potter, Scott C, Fujitaki, James M, van Poelje, Paul D, Huang, Jingwei, Lipscomb, William N, Erion, Mark D
Published in Journal of the American Chemical Society (19.12.2007)

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MB06322 (CS-917): A Potent and Selective Inhibitor of Fructose 1,6-Bisphosphatase for Controlling Gluconeogenesis in Type 2 Diabetes

MB06322 (CS-917): A Potent and Selective Inhibitor of Fructose 1,6-Bisphosphatase for Controlling Gluconeogenesis in Type 2 Diabetes

by Erion, Mark D., van Poelje, Paul D., Dang, Qun, Kasibhatla, Srinivas Rao, Potter, Scott C., Reddy, M. Rami, Reddy, K. Raja, Jiang, Tao, Lipscomb, William N.
Published in Proceedings of the National Academy of Sciences - PNAS (31.05.2005)

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Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats

Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats

by VAN POELJE, Paul D, POTTER, Scott C, CHANDRAMOULI, Visvanathan C, LANDAU, Bernard R, QUN DANG, ERION, Mark D
Published in Diabetes (New York, N.Y.) (01.06.2006)

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Liver-Targeted Drug Delivery Using HepDirect Prodrugs

Liver-Targeted Drug Delivery Using HepDirect Prodrugs

by Erion, Mark D, van Poelje, Paul D, Mackenna, Deidre A, Colby, Timothy J, Montag, Annika C, Fujitaki, James M, Linemeyer, David L, Bullough, David A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2005)

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Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

by CARROLL, Steven S, KOEPLINGER, Kenneth, FUJITAKI, James M, BOYER, Serge H, LINEMEYER, David L, HECKER, Scott J, ERION, Mark D, VAVREK, Marissa, NANYAN RENA ZHANG, HANDT, Laurence, MACCOSS, Malcolm, OLSEN, David B, RAJA REDDY, K, ZHILI SUN, VAN POELJE, Paul D
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)

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Preclinical Pharmacokinetics of a HepDirect Prodrug of a Novel Phosphonate-Containing Thyroid Hormone Receptor Agonist

Preclinical Pharmacokinetics of a HepDirect Prodrug of a Novel Phosphonate-Containing Thyroid Hormone Receptor Agonist

by Fujitaki, James M, Cable, Edward E, Ito, Bruce R, Zhang, Bao-Hong, Hou, Jinzhao, Yang, Chun, Bullough, David A, Ferrero, James L, van Poelje, Paul D, Linemeyer, David L, Erion, Mark D
Published in Drug metabolism and disposition (01.11.2008)

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Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase

Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase

by Dang, Qun, Liu, Yan, Cashion, Daniel K, Kasibhatla, Srinivas Rao, Jiang, Tao, Taplin, Frank, Jacintho, Jason D, Li, Haiqing, Sun, Zhili, Fan, Yi, DaRe, Jay, Tian, Feng, Li, Wenyu, Gibson, Tony, Lemus, Robert, van Poelje, Paul D, Potter, Scott C, Erion, Mark D
Published in Journal of medicinal chemistry (13.01.2011)

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Reduction of hepatic steatosis in rats and mice after treatment with a liver‐targeted thyroid hormone receptor agonist

Reduction of hepatic steatosis in rats and mice after treatment with a liver‐targeted thyroid hormone receptor agonist

by Cable, Edward E., Finn, Patricia D., Stebbins, Jeffrey W., Hou, Jinzhao, Ito, Bruce R., van Poelje, Paul D., Linemeyer, David L., Erion, Mark D.
Published in Hepatology (Baltimore, Md.) (01.02.2009)

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Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity

Structure-Guided Design of AMP Mimics That Inhibit Fructose-1,6-bisphosphatase with High Affinity and Specificity

by Erion, Mark D, Dang, Qun, Reddy, M. Rami, Kasibhatla, Srinivas Rao, Huang, Jingwei, Lipscomb, William N, van Poelje, Paul D
Published in Journal of the American Chemical Society (19.12.2007)

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Fructose-1,6-bisphosphatase Inhibitors. 2. Design, Synthesis, and Structure−Activity Relationship of a Series of Phosphonic Acid Containing Benzimidazoles that Function as 5′-Adenosinemonophosphate (AMP) Mimics

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, Synthesis, and Structure−Activity Relationship of a Series of Phosphonic Acid Containing Benzimidazoles that Function as 5′-Adenosinemonophosphate (AMP) Mimics

by Dang, Qun, Kasibhatla, Srinivas Rao, Xiao, Wei, Liu, Yan, DaRe, Jay, Taplin, Frank, Reddy, K. Raja, Scarlato, Gerard R, Gibson, Tony, van Poelje, Paul D, Potter, Scott C, Erion, Mark D
Published in Journal of medicinal chemistry (14.01.2010)

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Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B

Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B

by Reddy, K. Raja, Matelich, Michael C, Ugarkar, Bheemarao G, Gómez-Galeno, Jorge E, DaRe, Jay, Ollis, Kristin, Sun, Zhili, Craigo, William, Colby, Timothy J, Fujitaki, James M, Boyer, Serge H, van Poelje, Paul D, Erion, Mark D
Published in Journal of medicinal chemistry (14.02.2008)

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Discovery of Phosphonic Diamide Prodrugs and Their Use for the Oral Delivery of a Series of Fructose 1,6-Bisphosphatase Inhibitors

Discovery of Phosphonic Diamide Prodrugs and Their Use for the Oral Delivery of a Series of Fructose 1,6-Bisphosphatase Inhibitors

by Dang, Qun, Kasibhatla, Srinivas Rao, Jiang, Tao, Fan, Kevin, Liu, Yan, Taplin, Frank, Schulz, William, Cashion, Daniel K, Reddy, K. Raja, van Poelje, Paul D, Fujitaki, James M, Potter, Scott C, Erion, Mark D
Published in Journal of medicinal chemistry (24.07.2008)

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Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes

Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes

by van Poelje, Paul D, Potter, Scott C, Erion, Mark D
Published in Handbook of experimental pharmacology (01.01.2011)

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Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

by Sun, William, Wu, Rong Rong, van Poelje, Paul D., Erion, Mark D.
Published in Biochemical and biophysical research communications (04.05.2001)

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Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection

Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection

by Hecker, Scott J, Reddy, K. Raja, van Poelje, Paul D, Sun, Zhili, Huang, Wenjian, Varkhedkar, Vaibhav, Reddy, M. Venkat, Fujitaki, James M, Olsen, David B, Koeplinger, Kenneth A, Boyer, Serge H, Linemeyer, David L, MacCoss, Malcolm, Erion, Mark D
Published in Journal of medicinal chemistry (09.08.2007)

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Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration

Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration

by Dang, Qun, Liu, Yan, Rydzewski, Robert M., Brown, Brian S., Robinson, Edward, van Poelje, Paul D., Colby, Timothy J., Erion, Mark D.
Published in Bioorganic & medicinal chemistry letters (15.06.2007)

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Pyruvoyl-dependent enzymes

Pyruvoyl-dependent enzymes

by van Poelje, P D, Snell, E E
Published in Annual review of biochemistry (1990)

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LIVER TARGETING OF HEPATITIS-B ANTIVIRAL LAMIVUDINE USING THE HEPDIRECT™ PRODRUG TECHNOLOGY

LIVER TARGETING OF HEPATITIS-B ANTIVIRAL LAMIVUDINE USING THE HEPDIRECT™ PRODRUG TECHNOLOGY

by Reddy, K. Raja, Colby, Timothy J., Fujitaki, James M., van Poelje, Paul D., Erion, Mark D.
Published in Nucleosides, nucleotides & nucleic acids (01.01.2005)

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