A Charge‐Switchable Zwitterionic Peptide for Rapid Detection of SARS‐CoV‐2 Main Protease
Jin, Zhicheng, Mantri, Yash, Retout, Maurice, Cheng, Yong, Zhou, Jiajing, Jorns, Alec, Fajtova, Pavla, Yim, Wonjun, Moore, Colman, Xu, Ming, Creyer, Matthew N., Borum, Raina M., Zhou, Jingcheng, Wu, Zhuohong, He, Tengyu, Penny, William F., O'Donoghue, Anthony J., Jokerst, Jesse V.
Published in Angewandte Chemie International Edition (21.02.2022)
Published in Angewandte Chemie International Edition (21.02.2022)
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Journal Article
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders
Hook, Vivian, Yoon, Michael, Mosier, Charles, Ito, Gen, Podvin, Sonia, Head, Brian P., Rissman, Robert, O'Donoghue, Anthony J., Hook, Gregory
Published in Biochimica et biophysica acta. Proteins and proteomics (01.08.2020)
Published in Biochimica et biophysica acta. Proteins and proteomics (01.08.2020)
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A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding
Wendt, George, Zhao, Lu, Chen, Rui, Liu, Chenxi, O'Donoghue, Anthony J, Caffrey, Conor R, Reese, Michael L, Collins, 3rd, James J
Published in Science (American Association for the Advancement of Science) (25.09.2020)
Published in Science (American Association for the Advancement of Science) (25.09.2020)
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Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range
Yoon, Michael C., Hook, Vivian, O’Donoghue, Anthony J.
Published in Biochemistry (Easton) (06.09.2022)
Published in Biochemistry (Easton) (06.09.2022)
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Giant magnetoresistive biosensors for real-time quantitative detection of protease activity
Adem, Sandeep, Jain, Sonal, Sveiven, Michael, Zhou, Xiahan, O’Donoghue, Anthony J., Hall, Drew A.
Published in Scientific reports (14.05.2020)
Published in Scientific reports (14.05.2020)
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Journal Article
Structure- and function-based design of Plasmodium-selective proteasome inhibitors
Li, Hao, O’Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew
Published in Nature (London) (11.02.2016)
Published in Nature (London) (11.02.2016)
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Journal Article
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Julien, Olivier, Zhuang, Min, Wiita, Arun P., O’Donoghue, Anthony J., Knudsen, Giselle M., Craik, Charles S., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
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Journal Article
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV‑2 Infection of Human and Monkey Cells
Mellott, Drake M, Tseng, Chien-Te, Drelich, Aleksandra, Fajtová, Pavla, Chenna, Bala C, Kostomiris, Demetrios H, Hsu, Jason, Zhu, Jiyun, Taylor, Zane W, Kocurek, Klaudia I, Tat, Vivian, Katzfuss, Ardala, Li, Linfeng, Giardini, Miriam A, Skinner, Danielle, Hirata, Ken, Yoon, Michael C, Beck, Sungjun, Carlin, Aaron F, Clark, Alex E, Beretta, Laura, Maneval, Daniel, Hook, Vivian, Frueh, Felix, Hurst, Brett L, Wang, Hong, Raushel, Frank M, O’Donoghue, Anthony J, de Siqueira-Neto, Jair Lage, Meek, Thomas D, McKerrow, James H
Published in ACS chemical biology (16.04.2021)
Published in ACS chemical biology (16.04.2021)
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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions
Yoon, Michael C, Solania, Angelo, Jiang, Zhenze, Christy, Mitchell P, Podvin, Sonia, Mosier, Charles, Lietz, Christopher B, Ito, Gen, Gerwick, William H, Wolan, Dennis W, Hook, Gregory, O’Donoghue, Anthony J, Hook, Vivian
Published in ACS chemical biology (17.09.2021)
Published in ACS chemical biology (17.09.2021)
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Journal Article
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity
LaMonte, Gregory M, Almaliti, Jehad, Bibo-Verdugo, Betsaida, Keller, Lena, Zou, Bing Yu, Yang, Jennifer, Antonova-Koch, Yevgeniya, Orjuela-Sanchez, Pamela, Boyle, Colleen A, Vigil, Edgar, Wang, Lawrence, Goldgof, Gregory M, Gerwick, Lena, O’Donoghue, Anthony J, Winzeler, Elizabeth A, Gerwick, William H, Ottilie, Sabine
Published in Journal of medicinal chemistry (10.08.2017)
Published in Journal of medicinal chemistry (10.08.2017)
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Small molecule in situ resin capture provides a compound first approach to natural product discovery
Bogdanov, Alexander, Salib, Mariam N., Chase, Alexander B., Hammerlindl, Heinz, Muskat, Mitchell N., Luedtke, Stephanie, da Silva, Elany Barbosa, O’Donoghue, Anthony J., Wu, Lani F., Altschuler, Steven J., Molinski, Tadeusz F., Jensen, Paul R.
Published in Nature communications (19.06.2024)
Published in Nature communications (19.06.2024)
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Journal Article
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range
Yoon, Michael C., Phan, Von, Podvin, Sonia, Mosier, Charles, O’Donoghue, Anthony J., Hook, Vivian
Published in Biochemistry (Easton) (01.08.2023)
Published in Biochemistry (Easton) (01.08.2023)
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Journal Article
Skin Commensal Malassezia globosa Secreted Protease Attenuates Staphylococcus aureus Biofilm Formation
Li, Hao, Goh, Bee Na, Teh, Wooi Keong, Jiang, Zhenze, Goh, Joleen Pei Zhen, Goh, Amelia, Wu, Guangxi, Hoon, Shawn S., Raida, Manfred, Camattari, Andrea, Yang, Liang, O’Donoghue, Anthony J., Dawson, Thomas L.
Published in Journal of investigative dermatology (01.05.2018)
Published in Journal of investigative dermatology (01.05.2018)
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Journal Article
A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening
Cheng, Yong, Borum, Raina M., Clark, Alex E., Jin, Zhicheng, Moore, Colman, Fajtová, Pavla, O'Donoghue, Anthony J., Carlin, Aaron F., Jokerst, Jesse V.
Published in Angewandte Chemie International Edition (21.02.2022)
Published in Angewandte Chemie International Edition (21.02.2022)
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Journal Article
Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron
Keller, Laura J., Nguyen, Taylor H., Liu, Lawrence J., Hurysz, Brianna M., Lakemeyer, Markus, Guerra, Matteo, Gelsinger, Danielle J., Chanin, Rachael, Ngo, Nhi, Lum, Kenneth M., Faucher, Franco, Ipock, Phillip, Niphakis, Micah J., Bhatt, Ami S., O’Donoghue, Anthony J., Huang, Kerwyn Casey, Bogyo, Matthew
Published in Nature chemical biology (01.12.2023)
Published in Nature chemical biology (01.12.2023)
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Journal Article
Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase
O'Donoghue, Anthony J, Jin, Ye, Knudsen, Giselle M, Perera, Natascha C, Jenne, Dieter E, Murphy, John E, Craik, Charles S, Hermiston, Terry W
Published in PloS one (20.09.2013)
Published in PloS one (20.09.2013)
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Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors
Silhan, Jan, Fajtova, Pavla, Bartosova, Jitka, Hurysz, Brianna M., Almaliti, Jehad, Miyamoto, Yukiko, Eckmann, Lars, Gerwick, William H., O’Donoghue, Anthony J., Boura, Evzen
Published in Nature communications (04.10.2024)
Published in Nature communications (04.10.2024)
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Journal Article
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Mahoney, Matthew, Damalanka, Vishnu C, Tartell, Michael A, Chung, Dong Hee, Lourenço, André Luiz, Pwee, Dustin, Mayer Bridwell, Anne E, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P, Klingler, Andrea M, Rothlauf, Paul W, Thompson, Cassandra E, Lee, Melody, Klampfer, Lidija, Stallings, Christina L, Rothenberg, Marc E, Pöhlmann, Stefan, Whelan, Sean P J, O'Donoghue, Anthony J, Craik, Charles S, Janetka, James W
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
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A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of Porphyromonas gingivalis Enzymatic Activity
Retout, Maurice, Amer, Lubna, Yim, Wonjun, Creyer, Matthew N., Lam, Benjamin, Trujillo, Diego F., Potempa, Jan, O’Donoghue, Anthony J., Chen, Casey, Jokerst, Jesse V.
Published in ACS nano (12.09.2023)
Published in ACS nano (12.09.2023)
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