Recent developments in using mechanistic cardiac modelling for drug safety evaluation
Davies, Mark R., Wang, Ken, Mirams, Gary R., Caruso, Antonello, Noble, Denis, Walz, Antje, Lavé, Thierry, Schuler, Franz, Singer, Thomas, Polonchuk, Liudmila
Published in Drug discovery today (01.06.2016)
Published in Drug discovery today (01.06.2016)
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A novel strategy for physiologically based predictions of human pharmacokinetics
JONES, Hannah M, PARROTF, Neil, JORGA, Karin, LAVE, Thierry
Published in Clinical pharmacokinetics (01.01.2006)
Published in Clinical pharmacokinetics (01.01.2006)
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Journal Article
Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model
POIRIER, Agnès, LAVE, Thierry, PORTMANN, Renée, BRUN, Marie-Elise, SENNER, Frank, KANSY, Manfred, GRIMM, Hans-Peter, FUNK, Christoph
Published in Drug metabolism and disposition (01.12.2008)
Published in Drug metabolism and disposition (01.12.2008)
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Pharmacokinetic/Pharmacodynamic Predictors of Clinical Potency for Hepatitis C Virus Nonnucleoside Polymerase and Protease Inhibitors
Reddy, Micaela B, Morcos, Peter N, Le Pogam, Sophie, Ou, Ying, Frank, Karl, Lave, Thierry, Smith, Patrick
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
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Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog
Heikkinen, Aki T., Friedlein, Arno, Lamerz, Jens, Jakob, Peter, Cutler, Paul, Fowler, Stephen, Williamson, Tara, Tolando, Roberto, Lave, Thierry, Parrott, Neil
Published in Pharmaceutical research (01.07.2012)
Published in Pharmaceutical research (01.07.2012)
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Journal Article
Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations
Blanchard, Nadège, Hewitt, Nicola J, Silber, Paul, Jones, Hannah, Coassolo, Philippe, Lavé, Thierry
Published in Journal of pharmacy and pharmacology (01.05.2006)
Published in Journal of pharmacy and pharmacology (01.05.2006)
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Journal Article
Influence of molecular size on tissue distribution of antibody fragments
Li, Zhe, Krippendorff, Ben-Fillippo, Sharma, Sharad, Walz, Antje C, Lavé, Thierry, Shah, Dhaval K
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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Journal Article
Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: Influence of time between substrate and inducer administration
Baneyx, Guillaume, Parrott, Neil, Meille, Christophe, Iliadis, Athanassios, Lavé, Thierry
Published in European journal of pharmaceutical sciences (02.06.2014)
Published in European journal of pharmaceutical sciences (02.06.2014)
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Journal Article
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling
Kratochwil, Nicole A., Meille, Christophe, Fowler, Stephen, Klammers, Florian, Ekiciler, Aynur, Molitor, Birgit, Simon, Sandrine, Walter, Isabelle, McGinnis, Claudia, Walther, Johanna, Leonard, Brian, Triyatni, Miriam, Javanbakht, Hassan, Funk, Christoph, Schuler, Franz, Lavé, Thierry, Parrott, Neil J.
Published in The AAPS journal (01.03.2017)
Published in The AAPS journal (01.03.2017)
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Journal Article
Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans
Luttringer, Olivier, Theil, Frank‐Peter, Poulin, Patrick, Schmitt‐Hoffmann, Anne H., Guentert, Theodor Walter, Lavé, Thierry
Published in Journal of pharmaceutical sciences (01.10.2003)
Published in Journal of pharmaceutical sciences (01.10.2003)
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Journal Article
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance
Ring, Barbara J., Chien, Jenny Y., Adkison, Kimberly K., Jones, Hannah M., Rowland, Malcolm, Jones, Rhys Do, Yates, James W.T., Ku, M. Sherry, Gibson, Christopher R., He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Journal Article
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach
Poulin, Patrick, Jones, Rhys D.O., Jones, Hannah M., Gibson, Christopher R., Rowland, Malcolm, Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Yates, James W.T.
Published in Journal of pharmaceutical sciences (01.10.2011)
Published in Journal of pharmaceutical sciences (01.10.2011)
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Journal Article
Importance of target-mediated drug disposition for small molecules
Smith, Dennis A., van Waterschoot, Robert A.B., Parrott, Neil J., Olivares-Morales, Andrés, Lavé, Thierry, Rowland, Malcolm
Published in Drug discovery today (01.12.2018)
Published in Drug discovery today (01.12.2018)
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