Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket
Forster, Michael, Chaikuad, Apirat, Bauer, Silke M., Holstein, Julia, Robers, Matthew B., Corona, Cesear R., Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A.
Published in Cell chemical biology (17.11.2016)
Published in Cell chemical biology (17.11.2016)
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Quantifying CDK inhibitor selectivity in live cells
Wells, Carrow I., Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Ingold, Morgan R., Pickett, Julie E., Drewry, David H., Pugh, Kathryn M., Schwinn, Marie K., Hwang, Byounghoon (Brian), Zegzouti, Hicham, Huber, Kilian V. M., Cong, Mei, Meisenheimer, Poncho L., Willson, Timothy M., Robers, Matthew B.
Published in Nature communications (02.06.2020)
Published in Nature communications (02.06.2020)
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KRAS is vulnerable to reversible switch-II pocket engagement in cells
Vasta, James D., Peacock, D. Matthew, Zheng, Qinheng, Walker, Joel A., Zhang, Ziyang, Zimprich, Chad A., Thomas, Morgan R., Beck, Michael T., Binkowski, Brock F., Corona, Cesear R., Robers, Matthew B., Shokat, Kevan M.
Published in Nature chemical biology (01.06.2022)
Published in Nature chemical biology (01.06.2022)
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Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Hartnett, James R., Ingold, Morgan R., Zimmerman, Kristopher, Machleidt, Thomas, Kirkland, Thomas A., Huwiler, Kristin G., Ohana, Rachel Friedman, Slater, Michael, Otto, Paul, Cong, Mei, Wells, Carrow I., Berger, Benedict-Tilman, Hanke, Thomas, Glas, Carina, Ding, Ke, Drewry, David H., Huber, Kilian V.M., Willson, Timothy M., Knapp, Stefan, Müller, Susanne, Meisenheimer, Poncho L., Fan, Frank, Wood, Keith V., Robers, Matthew B.
Published in Cell chemical biology (15.02.2018)
Published in Cell chemical biology (15.02.2018)
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Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites
Wittlinger, Florian, Heppner, David E, To, Ciric, Günther, Marcel, Shin, Bo Hee, Rana, Jaimin K, Schmoker, Anna M, Beyett, Tyler S, Berger, Lena M, Berger, Benedict-Tilman, Bauer, Nicolas, Vasta, James D, Corona, Cesear R, Robers, Matthew B, Knapp, Stefan, Jänne, Pasi A, Eck, Michael J, Laufer, Stefan A
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Small-molecule inhibition of the archetypal UbiB protein COQ8
Murray, Nathan H., Asquith, Christopher R. M., Fang, Zixiang, East, Michael P., Ptak, Naomi, Smith, Robert W., Vasta, James D., Zimprich, Chad A., Corona, Cesear R., Robers, Matthew B., Johnson, Gary L., Bingman, Craig A., Pagliarini, David J.
Published in Nature chemical biology (01.02.2023)
Published in Nature chemical biology (01.02.2023)
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Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2
Němec, Václav, Remeš, Marek, Beňovský, Petr, Böck, Michael C., Šranková, Eliška, Wong, Jong Fu, Cros, Julien, Williams, Eleanor, Tse, Lap Hang, Smil, David, Ensan, Deeba, Isaac, Methvin B., Al-Awar, Rima, Gomolková, Regina, Ursachi, Vlad-Constantin, Fafílek, Bohumil, Kahounová, Zuzana, Víchová, Ráchel, Vacek, Ondřej, Berger, Benedict-Tilman, Wells, Carrow I., Corona, Cesear R., Vasta, James D., Robers, Matthew B., Krejci, Pavel, Souček, Karel, Bullock, Alex N., Knapp, Stefan, Paruch, Kamil
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Discovery of a selective inhibitor of doublecortin like kinase 1
Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.
Published in Nature chemical biology (01.06.2020)
Published in Nature chemical biology (01.06.2020)
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