Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant
Huang, Wei-Sheng, Metcalf, Chester A, Sundaramoorthi, Raji, Wang, Yihan, Zou, Dong, Thomas, R. Mathew, Zhu, Xiaotian, Cai, Lisi, Wen, David, Liu, Shuangying, Romero, Jan, Qi, Jiwei, Chen, Ingrid, Banda, Geetha, Lentini, Scott P, Das, Sasmita, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T, Broudy, Marc I, Russian, Karin, Zhou, Tianjun, Commodore, Lois, Narasimhan, Narayana I, Mohemmad, Qurish K, Iuliucci, John, Rivera, Victor M, Dalgarno, David C, Sawyer, Tomi K, Clackson, Tim, Shakespeare, William C
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
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Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery
Zech, Stephan G, Kohlmann, Anna, Zhou, Tianjun, Li, Feng, Squillace, Rachel M, Parillon, Lois E, Greenfield, Matthew T, Miller, David P, Qi, Jiwei, Thomas, R. Mathew, Wang, Yihan, Xu, Yongjin, Miret, Juan J, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David C
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation
Huang, Wei-Sheng, Zhu, Xiaotian, Wang, Yihan, Azam, Mohammad, Wen, David, Sundaramoorthi, Raji, Thomas, R. Mathew, Liu, Shuangying, Banda, Geetha, Lentini, Scott P, Das, Sasmita, Xu, Qihong, Keats, Jeff, Wang, Frank, Wardwell, Scott, Ning, Yaoyu, Snodgrass, Joseph T, Broudy, Marc I, Russian, Karin, Daley, George Q, Iuliucci, John, Dalgarno, David C, Clackson, Tim, Sawyer, Tomi K, Shakespeare, William C
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors
Kohlmann, Anna, Zech, Stephan G, Li, Feng, Zhou, Tianjun, Squillace, Rachel M, Commodore, Lois, Greenfield, Matthew T, Lu, Xiaohui, Miller, David P, Huang, Wei-Sheng, Qi, Jiwei, Thomas, R. Mathew, Wang, Yihan, Zhang, Sen, Dodd, Rory, Liu, Shuangying, Xu, Rongsong, Xu, Yongjin, Miret, Juan J, Rivera, Victor, Clackson, Tim, Shakespeare, William C, Zhu, Xiaotian, Dalgarno, David C
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Facile synthesis of 9-(arenethenyl)purines via Heck reaction of 9-vinylpurines and aryl halides
Huang, Wei-Sheng, Wang, Yihan, Sundaramoorthi, Raji, Thomas, R. Mathew, Wen, David, Liu, Shuangying, Lentini, Scott P., Das, Sasmita, Banda, Geetha, Sawyer, Tomi K., Shakespeare, William C.
Published in Tetrahedron letters (08.10.2007)
Published in Tetrahedron letters (08.10.2007)
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