A Practical Approach for Enantio- and Diastereocontrol in the Synthesis of 2,3-Disubstituted Succinic Acid Esters: Synthesis of the pan-Notch Inhibitor BMS-906024
Quesnelle, Claude A., Gill, Patrice, Kim, Soong-Hoon, Chen, Libing, Zhao, Yufen, Fink, Brian E., Saulnier, Mark, Frennesson, David, DeMartino, Michael P., Baran, Phil S., Gavai, Ashvinikumar V.
Published in Synlett (19.09.2016)
Published in Synlett (19.09.2016)
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Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization
Cherney, Emily C, Zhang, Liping, Lo, Julian, Huynh, Tram, Wei, Donna, Ahuja, Vijay, Quesnelle, Claude, Schieven, Gary L, Futran, Alan, Locke, Gregory A, Lin, Zeyu, Monereau, Laura, Chaudhry, Charu, Blum, Jordan, Li, Sha, Fereshteh, Mark, Li-Wang, Bifang, Gangwar, Sanjeev, Pan, Chin, Chong, Colin, Zhu, Xiao, Posy, Shana L, Sack, John S, Zhang, Ping, Ruzanov, Max, Harner, Mary, Akhtar, Fahad, Schroeder, Gretchen M, Vite, Gregory, Fink, Brian
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
Gavai, Ashvinikumar V, Norris, Derek, Delucca, George, Tortolani, David, Tokarski, John S, Dodd, Dharmpal, O’Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Han, Wen-Ching, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Poss, Michael, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Menard, Krista, Wen, Mei-Li, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Traeger, Sarah C, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, Everlof, Gerry, Raghavan, Nirmala, Tye, Ching Kim, Wee, Susan, Hunt, John T, Vite, Gregory, Westhouse, Richard, Lee, Francis Y
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype
Hill, Matthew D., Quesnelle, Claude, Tokarski, John, Fang, Haiquan, Fanslau, Carolynn, Haarhoff, Zuzana, Kramer, Melissa, Madari, Shilpa, Wiebesiek, Amy, Morrison, John, Simmermacher-Mayer, Jean, Sinz, Michael, Westhouse, Richard, Xie, Chunshan, Zhao, Jiuqiao, Huang, Lisa, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Everlof, Gerry, Zvyaga, Tatyana, Lee, Francis, Gavai, Ashvinikumar V., Degnan, Andrew P.
Published in Bioorganic & medicinal chemistry letters (01.11.2021)
Published in Bioorganic & medicinal chemistry letters (01.11.2021)
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Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties
Hill, Matthew D., Fang, Haiquan, Norris, Derek, Delucca, George V., Huang, Hong, DeBenedetto, Mikkel, Quesnelle, Claude, Schmitz, William D., Tokarski, John S., Sheriff, Steven, Yan, Chunhong, Fanslau, Caroline, Haarhoff, Zuzana, Huang, Christine, Kramer, Melissa, Madari, Shilpa, Menard, Krista, Monereau, Laura, Morrison, John, Raghavan, Nirmala, Shields, Eric E., Simmermacher-Mayer, Jean, Sinz, Michael, Tye, Ching Kim, Westhouse, Richard, Xie, Chunshan, Zhang, Haiying, Zhang, Lisa, Zvyaga, Tatyana, Lee, Francis, Gavai, Ashvinikumar V., Degnan, Andrew P.
Published in ACS medicinal chemistry letters (14.07.2022)
Published in ACS medicinal chemistry letters (14.07.2022)
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Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors
Gavai, Ashvinikumar V, Quesnelle, Claude, Norris, Derek, Han, Wen-Ching, Gill, Patrice, Shan, Weifang, Balog, Aaron, Chen, Ke, Tebben, Andrew, Rampulla, Richard, Wu, Dauh-Rurng, Zhang, Yingru, Mathur, Arvind, White, Ronald, Rose, Anne, Wang, Haiqing, Yang, Zheng, Ranasinghe, Asoka, D’Arienzo, Celia, Guarino, Victor, Xiao, Lan, Su, Ching, Everlof, Gerry, Arora, Vinod, Shen, Ding Ren, Cvijic, Mary Ellen, Menard, Krista, Wen, Mei-Li, Meredith, Jere, Trainor, George, Lombardo, Louis J, Olson, Richard, Baran, Phil S, Hunt, John T, Vite, Gregory D, Fischer, Bruce S, Westhouse, Richard A, Lee, Francis Y
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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BMS-871: A novel orally active pan-Notch inhibitor as an anticancer agent
Shan, Weifang, Balog, Aaron, Quesnelle, Claude, Gill, Patrice, Han, Wen-Ching, Norris, Derek, Mandal, Sunilkumar, Thiruvenkadam, Raja, Gona, Kiran Babu, Thiyagarajan, Kamalraj, Kandula, Sathiah, McGlinchey, Kelly, Menard, Krista, Wen, Mei-Li, Rose, Anne, White, Ronald, Guarino, Victor, Shen, Ding Ren, Cvijic, Mary Ellen, Ranasinghe, Asoka, Dai, Jun, Zhang, Yingru, Wu, Dauh-Rurng, Mathur, Arvind, Rampulla, Richard, Trainor, George, Hunt, John T., Vite, Gregory D., Westhouse, Richard, Lee, Francis Y., Gavai, Ashvinikumar V.
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
Published in Bioorganic & medicinal chemistry letters (01.05.2015)
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Journal Article
Novel Tricyclic Inhibitors of IκB Kinase
Kempson, James, Spergel, Steven H, Guo, Junqing, Quesnelle, Claude, Gill, Patrice, Belanger, Dominique, Dyckman, Alaric J, Li, Tianle, Watterson, Scott H, Langevine, Charles M, Das, Jagabandhu, Moquin, Robert V, Furch, Joseph A, Marinier, Anne, Dodier, Marco, Martel, Alain, Nirschl, David, Van Kirk, Katy, Burke, James R, Pattoli, Mark A, Gillooly, Kathleen, McIntyre, Kim W, Chen, Laishun, Yang, Zheng, Marathe, Punit H, Wang-Iverson, David, Dodd, John H, McKinnon, Murray, Barrish, Joel C, Pitts, William J
Published in Journal of medicinal chemistry (09.04.2009)
Published in Journal of medicinal chemistry (09.04.2009)
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