Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains
Lauer, Peter, Hanson, Bill, Lemmens, Edward E, Liu, Weiqun, Luckett, William S, Leong, Meredith L, Allen, Heather E, Skoble, Justin, Bahjat, Keith S, Freitag, Nancy E, Brockstedt, Dirk G, Dubensky, Thomas W. Jr
Published in Infection and Immunity (01.08.2008)
Published in Infection and Immunity (01.08.2008)
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Journal Article
Killed but Metabolically Active Bacillus anthracis Vaccines Induce Broad and Protective Immunity against Anthrax
Skoble, Justin, Beaber, John W, Gao, Yi, Lovchik, Julie A, Sower, Laurie E, Liu, Weiqun, Luckett, William, Peterson, Johnny W, Calendar, Richard, Portnoy, Daniel A, Lyons, C. Rick, Dubensky, Thomas W. Jr
Published in Infection and Immunity (01.04.2009)
Published in Infection and Immunity (01.04.2009)
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Journal Article
Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
Le, Dung T, Wang-Gillam, Andrea, Picozzi, Vincent, Greten, Tim F, Crocenzi, Todd, Springett, Gregory, Morse, Michael, Zeh, Herbert, Cohen, Deirdre, Fine, Robert L, Onners, Beth, Uram, Jennifer N, Laheru, Daniel A, Lutz, Eric R, Solt, Sara, Murphy, Aimee Luck, Skoble, Justin, Lemmens, Ed, Grous, John, Dubensky, Jr, Thomas, Brockstedt, Dirk G, Jaffee, Elizabeth M
Published in Journal of clinical oncology (20.04.2015)
Published in Journal of clinical oncology (20.04.2015)
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Journal Article
A First-in-Human Phase 1, Multicenter, Open-Label Study of CB-010, a Next-Generation CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy with a PD-1 Knockout, in Patients with Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER Study)
O'Brien, Susan, Nastoupil, Loretta J., Essell, James, Dsouza, Ly, Hart, Doug, Matsuda, Emiri, Satterfield, Tarah, Nesheiwat, Tonia, Hammad, Ashley, Davi, Franco, Chung, Shally, Shamsi, S. Asim, Bryan, Mara, Skoble, Justin, Garner, Elizabeth, Kanner, Steven, Rizvi, Syed, Holmes, Houston
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Abstract 4782: STACT: A novel tumor-targeting, systemically-administered delivery platform capable of targeting intractable pathways and precise immunomodulation of the tumor microenvironment
Rae, Chris S., Besprozvannaya, Marina, Faulhaber, John, Makarova, Anastasia M., King, Beverly, Glickman, Laura Hix, Thanos, Christopher D., Skoble, Justin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
CLL-1-Targeted Allogeneic CAR-T Cells Exhibit High on-Target Specificity and Potent Cytotoxicity in Preclinical Models of Acute Myeloid Leukemia
Francica, Brian, Garner, Elizabeth, Namburi, Sai, Colgan, Cian, Fowler, Tristan, Mutha, Devin, Aviles, Art, Stanaway, Morena, Guo, Raymond, An, Zili, Kelly, Erin, Degagne, Emilie, Kwong, George, Edwards, Leslie, Jakes, Emma, Shaw, McKay, Schilling, Benjamin, Huynh, Jeremy, Luu, Ricky, Sidorov, Max, Mousali, Rhonda, Otsmaa, Mikk, Lauer, Peter, Skoble, Justin, Kanner, Steven
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
A first-in-human phase 1, multicenter, open-label study of CB-011, a next-generation CRISPR-genome edited allogeneic anti-BCMA immune-cloaked CAR-T cell therapy, in patients with relapsed/refractory multiple myeloma (CAMMOUFLAGE trial)
Berdeja, Jesus G., Martin, Thomas G., Rossi, Adriana, Essell, James H., Siegel, David Samuel DiCapua, Mailankody, Sham, Saini, Neeraj, Holmes, Houston, Dhakal, Binod, Gasparetto, Cristina J., Parekh, Samir S., Portella, Socorro, Ledergor, Guy, Hammad, Ashley, Davi, Franco, Skoble, Justin, Garner, Elizabeth, Kanner, Steven Brian, Rizvi, Syed, Jagannath, Sundar
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Abstract 5016: STACT-TREX1: A systemically-administered STING pathway agonist targets tumor-resident myeloid cells and induces adaptive anti-tumor immunity in multiple preclinical models
Makarova, Anastasia M., Iannello, Alexandre, Rae, Chris S., King, Beverly, Besprozvannaya, Marina, Faulhaber, John, Skoble, Justin, Thanos, Christopher D., Glickman, Laura Hix
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
A Potent and Effective Suicidal Listeria Vaccine Platform
Hanson, William G, Benanti, Erin L, Lemmens, Edward E, Liu, Weiqun, Skoble, Justin, Leong, Meredith L, Rae, Chris S, Fassò, Marcella, Brockstedt, Dirk G, Chen, Chen, Portnoy, Daniel A, Dubensky, Jr, Thomas W, Lauer, Peter
Published in Infection and immunity (01.08.2019)
Published in Infection and immunity (01.08.2019)
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Journal Article
Bion-1301, a First-in-Class APRIL Neutralizing Antibody for the Treatment of Multiple Myeloma: Preclinical Safety, and Analysis of Pharmacokinetics — Pharmacodynamics Relationship
Dulos, John, Driessen, Lilian, van Zandvoort, Peter, van de Crommert, Jos, Skoble, Justin, Nair, Nitya, Randlev, Britta, de Cock, Eduard, Elassaiss Schaap, Jeroen, Eenennaam, Hans, van Elsas, Andrea
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Abstract 6323: Preclinical evaluation of CB-012, an allogeneic anti-CLL-1 CAR-T cell therapy, that exhibits specific and potent toxicity in acute myeloid leukemia (AML) xenograft models
Francica, Brian, Garner, Elizabeth, Namburi, Sai, Colgan, Cian, Fowler, Tristan, Mutha, Devin, Aviles, Art, Stanaway, Morena, Guo, Raymond, An, Zili, Kelly, Erin, Degagne, Emilie, Kwong, George, Edwards, Leslie, Jakes, Emma, Shaw, McKay, Schilling, Benjamin, Huynh, Jeremy, Luu, Ricky, Sidorov, Max, Mousali, Rhonda, Otsmaa, Mikk, Lauer, Peter, Skoble, Justin, Kanner, Steven
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract LB009: A BCMA-specific allogeneic CAR-T cell therapy (CB-011) genome-engineered to express an HLA-E fusion transgene to prevent immune cell rejection
Garner, Elizabeth, Degagne, Emilie, Roy, Suparna, Donohoue, Paul, Fowler, Tristan, Stanaway, Morena, Vicena, Vanina, Mutha, Devin, Schilling, Benjamin, Shaw, McKay, Bryan, Mara, Edwards, Leslie, Smith, Stephen, Kohrs, Bryan, Banh, Lynda, McSweeney, Kyle, Skoble, Justin, Kanner, Steven
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 3201: CB-012, an allogeneic anti-CLL-1 CAR-T cell therapy engineered with next-generation CRISPR technology to resist both the immunosuppressive tumor microenvironment and immune cell-mediated rejection, for patients with relapsed or refractory acute myeloid leukemia
Garner, Elizabeth, Kelly, Erin, Namburi, Sai, Colgan, Cian, Fowler, Tristan, Mutha, Devin, Aviles, Art, Stanaway, Morena, Guo, Raymond, An, Zili, Degagne, Emilie, Kwong, George, Edwards, Leslie, Jakes, Emma, Shaw, McKay, Schilling, Benjamin, Huynh, Jeremy, Luu, Ricky, Sidorov, Max, Mousali, Rhonda, Otsmaa, Mikk, Skoble, Justin, Kanner, Steven
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Phase I study of safety and immunogenicity of ADU-623, a live-attenuated Listeria monocytogenes vaccine (Δ actA /Δ inlB ) expressing EGFRvIII and NY-ESO-1, in patients with WHO grade III/IV astrocytomas
Crittenden, Marka, Bahjat, Keith S., Li, Rui, Gore, Pankaj A., Fountain, Chris, Hanson, Bill, Skoble, Justin, Lauer, Peter, Murphy, Aimee, Dubensky, Thomas Walter, Brockstedt, Dirk G., Urba, Walter John
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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A phase 2b, randomized, controlled, multicenter, open-label study of the efficacy and immune response of GVAX pancreas vaccine and CRS-207 compared to chemotherapy or to CRS-207 alone in adults with previously treated metastatic pancreatic adenocarcinoma (ECLIPSE Study)
Le, Dung T., Wang-Gillam, Andrea, Picozzi, Vincent J., Crocenzi, Todd S., Morse, Michael, Zeh, Herbert, Fine, Robert Lance, Murphy, Aimee, Skoble, Justin, Lemmens, Ed, Ferber, Sandy, Rosen, Allan, Grous, John J., Dubensky, Thomas, Brockstedt, Dirk G., Jaffee, Elizabeth M.
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Journal Article
Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA Protein in Actin Filament Nucleation
Welch, Matthew D., Rosenblatt, Jody, Skoble, Justin, Portnoy, Daniel A., Mitchison, Timothy J.
Published in Science (American Association for the Advancement of Science) (03.07.1998)
Published in Science (American Association for the Advancement of Science) (03.07.1998)
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Journal Article
A phase IIb, randomized, controlled, multicenter, open-label study of the efficacy and immune response of GVAX pancreas vaccine and CRS-207 compared to chemotherapy or to CRS-207 alone in adults with previously treated metastatic pancreatic adenocarcinoma (ECLIPSE Study)
Le, Dung T., Wang-Gillam, Andrea, Picozzi, Vincent J., Crocenzi, Todd S., Morse, Michael, Zeh, Herbert, Fine, Robert Lance, Murphy, Aimee, Skoble, Justin, Lemmens, Ed, Ferber, Sandy, Rosen, Allan, Grous, John J., Dubensky, Thomas, Brockstedt, Dirk G., Lutz, Eric, Jaffee, Elizabeth M.
Published in Journal of clinical oncology (20.01.2015)
Published in Journal of clinical oncology (20.01.2015)
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Journal Article
A phase 2, randomized trial of GVAX pancreas and CRS-207 immunotherapy versus GVAX alone in patients with metastatic pancreatic adenocarcinoma: Updated results
Le, Dung T., Wang-Gillam, Andrea, Picozzi, Jr, Vincent, Greten, Tim F., Crocenzi, Todd S., Springett, Gregory M., Morse, Michael, Zeh, Herbert, Cohen, Deirdre Jill, Fine, Robert Lance, Onners, Beth, Uram, Jennifer N., Laheru, Dan, Murphy, Aimee, Skoble, Justin, Lemmens, Ed, Grous, John J., Dubensky, Thomas, Brockstedt, Dirk G., Jaffee, Elizabeth M.
Published in Journal of clinical oncology (20.01.2014)
Published in Journal of clinical oncology (20.01.2014)
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Journal Article
Interim safety and efficacy analysis of a phase II, randomized study of GVAX pancreas and CRS-207 immunotherapy in patients with metastatic pancreatic cancer
Le, Dung T., Wang-Gillam, Andrea, Picozzi, Vincent J., Greten, Tim F., Crocenzi, Todd S., Springett, Gregory M., Morse, Michael, Zeh, Herbert, Cohen, Deirdre Jill, Fine, Robert Lance, Onners, Beth, Uram, Jennifer N., Murphy, Aimee, Skoble, Justin, Lemmens, Ed, Grous, John J., Dubensky, Thomas, Brockstedt, Dirk G., Jaffee, Elizabeth M.
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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