A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding
Wendt, George, Zhao, Lu, Chen, Rui, Liu, Chenxi, O'Donoghue, Anthony J, Caffrey, Conor R, Reese, Michael L, Collins, 3rd, James J
Published in Science (American Association for the Advancement of Science) (25.09.2020)
Published in Science (American Association for the Advancement of Science) (25.09.2020)
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Journal Article
Giant magnetoresistive biosensors for real-time quantitative detection of protease activity
Adem, Sandeep, Jain, Sonal, Sveiven, Michael, Zhou, Xiahan, O’Donoghue, Anthony J., Hall, Drew A.
Published in Scientific reports (14.05.2020)
Published in Scientific reports (14.05.2020)
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Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Julien, Olivier, Zhuang, Min, Wiita, Arun P., O’Donoghue, Anthony J., Knudsen, Giselle M., Craik, Charles S., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.04.2016)
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Journal Article
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV‑2 Infection of Human and Monkey Cells
Mellott, Drake M, Tseng, Chien-Te, Drelich, Aleksandra, Fajtová, Pavla, Chenna, Bala C, Kostomiris, Demetrios H, Hsu, Jason, Zhu, Jiyun, Taylor, Zane W, Kocurek, Klaudia I, Tat, Vivian, Katzfuss, Ardala, Li, Linfeng, Giardini, Miriam A, Skinner, Danielle, Hirata, Ken, Yoon, Michael C, Beck, Sungjun, Carlin, Aaron F, Clark, Alex E, Beretta, Laura, Maneval, Daniel, Hook, Vivian, Frueh, Felix, Hurst, Brett L, Wang, Hong, Raushel, Frank M, O’Donoghue, Anthony J, de Siqueira-Neto, Jair Lage, Meek, Thomas D, McKerrow, James H
Published in ACS chemical biology (16.04.2021)
Published in ACS chemical biology (16.04.2021)
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Journal Article
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions
Yoon, Michael C, Solania, Angelo, Jiang, Zhenze, Christy, Mitchell P, Podvin, Sonia, Mosier, Charles, Lietz, Christopher B, Ito, Gen, Gerwick, William H, Wolan, Dennis W, Hook, Gregory, O’Donoghue, Anthony J, Hook, Vivian
Published in ACS chemical biology (17.09.2021)
Published in ACS chemical biology (17.09.2021)
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Journal Article
Skin Commensal Malassezia globosa Secreted Protease Attenuates Staphylococcus aureus Biofilm Formation
Li, Hao, Goh, Bee Na, Teh, Wooi Keong, Jiang, Zhenze, Goh, Joleen Pei Zhen, Goh, Amelia, Wu, Guangxi, Hoon, Shawn S., Raida, Manfred, Camattari, Andrea, Yang, Liang, O’Donoghue, Anthony J., Dawson, Thomas L.
Published in Journal of investigative dermatology (01.05.2018)
Published in Journal of investigative dermatology (01.05.2018)
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Journal Article
Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase
O'Donoghue, Anthony J, Jin, Ye, Knudsen, Giselle M, Perera, Natascha C, Jenne, Dieter E, Murphy, John E, Craik, Charles S, Hermiston, Terry W
Published in PloS one (20.09.2013)
Published in PloS one (20.09.2013)
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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Mahoney, Matthew, Damalanka, Vishnu C, Tartell, Michael A, Chung, Dong Hee, Lourenço, André Luiz, Pwee, Dustin, Mayer Bridwell, Anne E, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P, Klingler, Andrea M, Rothlauf, Paul W, Thompson, Cassandra E, Lee, Melody, Klampfer, Lidija, Stallings, Christina L, Rothenberg, Marc E, Pöhlmann, Stefan, Whelan, Sean P J, O'Donoghue, Anthony J, Craik, Charles S, Janetka, James W
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (26.10.2021)
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Journal Article
Insights into the catalytic properties of the mitochondrial rhomboid protease PARL
Lysyk, Laine, Brassard, Raelynn, Arutyunova, Elena, Siebert, Verena, Jiang, Zhenze, Takyi, Emmanuella, Morrison, Melissa, Young, Howard S., Lemberg, Marius K., O’Donoghue, Anthony J., Lemieux, M. Joanne
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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Journal Article
Tutuilamides A–C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties
Keller, Lena, Canuto, Kirley Marques, Liu, Chenxi, Suzuki, Brian M, Almaliti, Jehad, Sikandar, Asfandyar, Naman, C. Benjamin, Glukhov, Evgenia, Luo, Danmeng, Duggan, Brendan M, Luesch, Hendrik, Koehnke, Jesko, O’Donoghue, Anthony J, Gerwick, William H
Published in ACS chemical biology (20.03.2020)
Published in ACS chemical biology (20.03.2020)
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Journal Article
20S Proteasome as a Drug Target in Trichomonas vaginalis
O'Donoghue, Anthony J, Bibo-Verdugo, Betsaida, Miyamoto, Yukiko, Wang, Steven C, Yang, Justin Z, Zuill, Douglas E, Matsuka, Shoun, Jiang, Zhenze, Almaliti, Jehad, Caffrey, Conor R, Gerwick, William H, Eckmann, Lars
Published in Antimicrobial agents and chemotherapy (01.11.2019)
Published in Antimicrobial agents and chemotherapy (01.11.2019)
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Journal Article
Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing
Jiang, Zhenze, Lietz, Christopher B, Podvin, Sonia, Yoon, Michael C, Toneff, Thomas, Hook, Vivian, O’Donoghue, Anthony J
Published in ACS chemical neuroscience (07.07.2021)
Published in ACS chemical neuroscience (07.07.2021)
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Journal Article
Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses
Podvin, Sonia, Jones, Alexander, Liu, Qing, Aulston, Brent, Ransom, Linnea, Ames, Janneca, Shen, Gloria, Lietz, Christopher B., Jiang, Zhenze, O'Donoghue, Anthony J., Winston, Charisse, Ikezu, Tsuneya, Rissman, Robert A., Yuan, Shauna, Hook, Vivian
Published in Molecular & cellular proteomics (01.06.2020)
Published in Molecular & cellular proteomics (01.06.2020)
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Journal Article
Targeting proteasomes in infectious organisms to combat disease
Bibo‐Verdugo, Betsaida, Jiang, Zhenze, Caffrey, Conor R., O'Donoghue, Anthony J.
Published in The FEBS journal (01.05.2017)
Published in The FEBS journal (01.05.2017)
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Journal Article
High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma
Maffioli, Elisa, Jiang, Zhenze, Nonnis, Simona, Negri, Armando, Romeo, Valentina, Lietz, Christopher B, Hook, Vivian, Ristagno, Giuseppe, Baselli, Giuseppe, Kistler, Erik B, Aletti, Federico, O'Donoghue, Anthony J, Tedeschi, Gabriella
Published in Molecules (Basel, Switzerland) (06.09.2020)
Published in Molecules (Basel, Switzerland) (06.09.2020)
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Journal Article
The human pathobiont Malassezia furfur secreted protease Mfsap1 regulates cell dispersal and exacerbates skin inflammation
Goh, Joleen P Z, Ruchti, Fiorella, Poh, Si En, Koh, Winston L C, Tan, Kiat Yi, Lim, Yan Ting, Thng, Steven T G, Sobota, Radoslaw M, Hoon, Shawn S, Liu, Chenxi, O'Donoghue, Anthony J, LeibundGut-Landmann, Salomé, Oon, Hazel H, Li, Hao, Dawson, Jr, Thomas L
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2022)
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Journal Article
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties
Leontovyč, Adrian, Ulrychová, Lenka, O'Donoghue, Anthony J, Vondrášek, Jiří, Marešová, Lucie, Hubálek, Martin, Fajtová, Pavla, Chanová, Marta, Jiang, Zhenze, Craik, Charles S, Caffrey, Conor R, Mareš, Michael, Dvořák, Jan, Horn, Martin
Published in PLoS neglected tropical diseases (20.04.2018)
Published in PLoS neglected tropical diseases (20.04.2018)
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Journal Article
Immunoproteasome functions explained by divergence in cleavage specificity and regulation
Winter, Michael B, La Greca, Florencia, Arastu-Kapur, Shirin, Caiazza, Francesco, Cimermancic, Peter, Buchholz, Tonia J, Anderl, Janet L, Ravalin, Matthew, Bohn, Markus F, Sali, Andrej, O'Donoghue, Anthony J, Craik, Charles S
Published in eLife (28.11.2017)
Published in eLife (28.11.2017)
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Journal Article
Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
Meewan, Ittipat, Kattoula, Jacob, Kattoula, Julius Y., Skinner, Danielle, Fajtová, Pavla, Giardini, Miriam A., Woodworth, Brendon, McKerrow, James H., Lage de Siqueira-Neto, Jair, O’Donoghue, Anthony J., Abagyan, Ruben
Published in Pharmaceuticals (Basel, Switzerland) (13.06.2022)
Published in Pharmaceuticals (Basel, Switzerland) (13.06.2022)
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