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Published in Circulation (New York, N.Y.) (23.11.2021)
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Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
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Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin
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Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2018)
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Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state
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Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2021)
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Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
Liu, Chao, Karabina, Anastasia, Meller, Artur, Bhattacharjee, Ayan, Agostino, Colby J, Bowman, Greg R, Ruppel, Kathleen M, Spudich, James A, Leinwand, Leslie A
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Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2024)
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Dilated cardiomyopathy myosin mutants have reduced force-generating capacity
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Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation
Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M., Olivotto, Iacopo, Bustamante, Carlos D., Dewey, Frederick E., Ho, Carolyn Y., Spudich, James A., Ashley, Euan A.
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Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2016)
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Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Cell reports (Cambridge) (13.12.2016)
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Accessing the Low-Polar Molecular Composition of Boreal and Arctic Peat-Burning Organic Aerosol via Thermal Analysis and Ultrahigh-Resolution Mass Spectrometry: Structural Motifs and Their Formation
Schneider, Eric, Neumann, Anika, Chacón-Patiño, Martha L., Somero, Markus, Ruppel, Meri M., Ihalainen, Mika, Köster, Kajar, Sippula, Olli, Czech, Hendryk, Rüger, Christopher P., Zimmermann, Ralf
Published in Journal of the American Society for Mass Spectrometry (07.08.2024)
Published in Journal of the American Society for Mass Spectrometry (07.08.2024)
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Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties
Vera, Carlos D., Johnson, Chloe A., Walklate, Jonathan, Adhikari, Arjun, Svicevic, Marina, Mijailovich, Srboljub M., Combs, Ariana C., Langer, Stephen J., Ruppel, Kathleen M., Spudich, James A., Geeves, Michael A., Leinwand, Leslie A.
Published in The Journal of biological chemistry (15.11.2019)
Published in The Journal of biological chemistry (15.11.2019)
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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness
Gyimesi, Máté, Horváth, Ádám I., Túrós, Demeter, Suthar, Sharad Kumar, Pénzes, Máté, Kurdi, Csilla, Canon, Louise, Kikuti, Carlos, Ruppel, Kathleen M., Trivedi, Darshan V., Spudich, James A., Lőrincz, István, Rauscher, Anna Á., Kovács, Mihály, Pál, Endre, Komoly, Sámuel, Houdusse, Anne, Málnási-Csizmadia, András
Published in Cell (15.10.2020)
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Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
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Published in Journal of experimental biology (01.01.2016)
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Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2024)
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