An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme
Ceccarelli, Derek F., Tang, Xiaojing, Pelletier, Benoit, Orlicky, Stephen, Xie, Weilin, Plantevin, Veronique, Neculai, Dante, Chou, Yang-Chieh, Ogunjimi, Abiodun, Al-Hakim, Abdallah, Varelas, Xaralabos, Koszela, Joanna, Wasney, Gregory A., Vedadi, Masoud, Dhe-Paganon, Sirano, Cox, Sarah, Xu, Shuichan, Lopez-Girona, Antonia, Mercurio, Frank, Wrana, Jeff, Durocher, Daniel, Meloche, Sylvain, Webb, David R., Tyers, Mike, Sicheri, Frank
Published in Cell (24.06.2011)
Published in Cell (24.06.2011)
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Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
Chen, Qing, Xie, Weilin, Kuhn, Deborah J., Voorhees, Peter M., Lopez-Girona, Antonia, Mendy, Derek, Corral, Laura G., Krenitsky, Veronique Plantevin, Xu, Weiming, Moutouh-de Parseval, Laure, Webb, David R., Mercurio, Frank, Nakayama, Keiichi I., Nakayama, Keiko, Orlowski, Robert Z.
Published in Blood (01.05.2008)
Published in Blood (01.05.2008)
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Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination
Tang, Xiaojing, Orlicky, Stephen, Lin, Zhenyuan, Willems, Andrew, Neculai, Dante, Ceccarelli, Derek, Mercurio, Frank, Shilton, Brian H., Sicheri, Frank, Tyers, Mike
Published in Cell (15.06.2007)
Published in Cell (15.06.2007)
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Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway
Zhang, You-Wei, Otterness, Diane M., Chiang, Gary G., Xie, Weilin, Liu, Yun-Cai, Mercurio, Frank, Abraham, Robert T.
Published in Molecular cell (02.09.2005)
Published in Molecular cell (02.09.2005)
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Protacs: Chimeric Molecules That Target Proteins to the Skp1-Cullin-F Box Complex for Ubiquitination and Degradation
Sakamoto, K M, Kim, K B, Kumagai, A, Mercurio, F, Crews, C M, Deshaies, R J
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (17.07.2001)
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Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases
Xu, Yibing, Li, Jianwu, Ferguson, Gregory D., Mercurio, Frank, Khambatta, Gody, Morrison, Lisa, Lopez-Girona, Antonia, Corral, Laura G., Webb, David R., Bennett, Brydon L., Xie, Weilin
Published in Blood (09.07.2009)
Published in Blood (09.07.2009)
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Activation of NF-κB is Required for Hypertrophic Growth of Primary Rat Neonatal Ventricular Cardiomyocytes
Purcell, Nicole H., Tang, Guilin, Yu, Chenfei, Mercurio, Frank, DiDonato, Joseph A., Lin, Anning
Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (05.06.2001)
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Enhanced NF-κB Activation and Cellular Function in Macrophages Lacking IκB Kinase 1 (IKK1)
Li, Quitang, Lu, Qingxian, Bottero, Virginie, Estepa, Gabriela, Morrison, Lisa, Mercurio, Frank, Verma, Inder M.
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (30.08.2005)
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IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex
Mercurio, Frank, Murray, Brion W., Shevchenko, Andrej, Bennett, Brydon L., Young, David B., Li, Jian Wu, Pascual, Gabriel, Motiwala, Aparna, Zhu, Hengyi, Mann, Matthias, Manning, Anthony M.
Published in Molecular and Cellular Biology (01.02.1999)
Published in Molecular and Cellular Biology (01.02.1999)
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Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase
Xu, Shuichan, Abbasian, Mahan, Patel, Palka, Jensen-Pergakes, Kristen, Lombardo, Christian R., Cathers, Brian E., Xie, Weilin, Mercurio, Frank, Pagano, Michele, Giegel, David, Cox, Sarah
Published in The Journal of biological chemistry (25.05.2007)
Published in The Journal of biological chemistry (25.05.2007)
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Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models
Minzel, Waleed, Venkatachalam, Avanthika, Fink, Avner, Hung, Eric, Brachya, Guy, Burstain, Ido, Shaham, Maya, Rivlin, Amitai, Omer, Itay, Zinger, Adar, Elias, Shlomo, Winter, Eitan, Erdman, Paul E., Sullivan, Robert W., Fung, Leah, Mercurio, Frank, Li, Dansu, Vacca, Joseph, Kaushansky, Nathali, Shlush, Liran, Oren, Moshe, Levine, Ross, Pikarsky, Eli, Snir-Alkalay, Irit, Ben-Neriah, Yinon
Published in Cell (20.09.2018)
Published in Cell (20.09.2018)
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BTX-1188, a first-in-class dual degrader of GSPT1 and IKZF1/3, for treatment of acute myeloid leukemia (AML) and solid tumors
Chourasia, Aparajita Hoskote, Majeski, Hannah, Pasis, Angela, Erdman, Paul, Oke, Ashwini, Hecht, David, Lonergan, David, Mercurio, Frank, Chan, Kyle, Thai, Dung Luong, Fung, Leah
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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ATM and the Catalytic Subunit of DNA-Dependent Protein Kinase Activate NF-κB through a Common MEK/Extracellular Signal-Regulated Kinase/p90rsk Signaling Pathway in Response to Distinct Forms of DNA Damage
Panta, G R, Kaur, S, Cavin, L G, Cortes, M L, Mercurio, F, Lothstein, L, Sweatman, T W, Israel, M, Arsura, M
Published in Molecular and Cellular Biology (01.03.2004)
Published in Molecular and Cellular Biology (01.03.2004)
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Journal Article
Suprafacial Orientation of the SCF[superscript Cdc4] Dimer Accommodates Multiple Geometries for Substrate Ubiquitination
Tang, Xiaojing, Orlicky, Stephen, Lin, Zhenyuan, Willems, Andrew, Neculai, Dante, Ceccarelli, Derek, Mercurio, Frank, Shilton, Brian H., Sicheri, Frank, Tyers, Mike
Published in Cell (15.07.2008)
Published in Cell (15.07.2008)
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Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators
Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies
Fung, Leah, Chourasia, Aparajita Hoskote, Torres, Eduardo, Lam, Imelda, Erdman, Paul, Hecht, David, Sullivan, Robert, McElwee, Brooke, Richard, Normand, Venkatachalam, Avanthika, Snir-Alkalay, Irit, Chan, Kyle WH, Mercurio, Frank, Ben-Neriah, Yinon, Stirling, David I
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators
Chourasia, Aparajita Hoskote, Fung, Leah, McElwee, Brooke, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle WH, Mercurio, Frank, Stirling, David I
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Targeting the Transcriptional Addiction of Leukemia Stem Cells By a New Class of Protein Kinase Inhibitors
Ben-Neriah, Yinon, Venkatachalam, Avanthika, Fink, Avner, Hung, Eric, Vacca, Joseph, Mercurio, Frank, Oren, Moshe, Pikarsky, Eli, Snir-Alkalay, Irit, Minzel, Waleed
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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