A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells
Carusillo, Antonio, Haider, Sibtain, Schäfer, Raul, Rhiel, Manuel, Türk, Daniel, Chmielewski, Kay O, Klermund, Julia, Mosti, Laura, Andrieux, Geoffroy, Schäfer, Richard, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Published in Nucleic acids research (22.05.2023)
Published in Nucleic acids research (22.05.2023)
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Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells
Patsali, Petros, Turchiano, Giandomenico, Papasavva, Panayiota, Romito, Marianna, Loucari, Constantinos C, Stephanou, Coralea, Christou, Soteroulla, Sitarou, Maria, Mussolino, Claudio, Cornu, Tatjana I, Antoniou, Michael N, Lederer, Carsten W, Cathomen, Toni, Kleanthous, Marina
Published in Haematologica (Roma) (01.11.2019)
Published in Haematologica (Roma) (01.11.2019)
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CRISPR-Cas12a for Highly Efficient and Marker-Free Targeted Integration in Human Pluripotent Stem Cells
Hammad, Ruba, Alzubi, Jamal, Rhiel, Manuel, Chmielewski, Kay O, Mosti, Laura, Rositzka, Julia, Heugel, Marcel, Lawrenz, Jan, Pennucci, Valentina, Gläser, Birgitta, Fischer, Judith, Schambach, Axel, Moritz, Thomas, Lachmann, Nico, Cornu, Tatjana I, Mussolino, Claudio, Schäfer, Richard, Cathomen, Toni
Published in International journal of molecular sciences (01.01.2024)
Published in International journal of molecular sciences (01.01.2024)
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Automated generation of gene-edited CAR T cells at clinical scale
Alzubi, Jamal, Lock, Dominik, Rhiel, Manuel, Schmitz, Sabrina, Wild, Stefan, Mussolino, Claudio, Hildenbeutel, Markus, Brandes, Caroline, Rositzka, Julia, Lennartz, Simon, Haas, Simone A., Chmielewski, Kay O., Schaser, Thomas, Kaiser, Andrew, Cathomen, Toni, Cornu, Tatjana I.
Published in Molecular therapy. Methods & clinical development (12.03.2021)
Published in Molecular therapy. Methods & clinical development (12.03.2021)
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Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion
Söllü, Cem, Pars, Kaweh, Cornu, Tatjana I, Thibodeau-Beganny, Stacey, Maeder, Morgan L, Joung, J Keith, Heilbronn, Regine, Cathomen, Toni
Published in Nucleic acids research (01.12.2010)
Published in Nucleic acids research (01.12.2010)
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Cell-Based Models of 'Cytokine Release Syndrome' Endorse CD40L and Granulocyte-Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy
Dibas, Ala, Rhiel, Manuel, Patel, Vidisha Bhavesh, Andrieux, Geoffroy, Boerries, Melanie, Cornu, Tatjana I, Alzubi, Jamal, Cathomen, Toni
Published in Cells (Basel, Switzerland) (01.11.2023)
Published in Cells (Basel, Switzerland) (01.11.2023)
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Allele-Specific Disruption of a Common STAT3 Autosomal Dominant Allele Is Not Sufficient to Restore Downstream Signaling in Patient-Derived T Cells
König, Saskia, Fliegauf, Manfred, Rhiel, Manuel, Grimbacher, Bodo, Cornu, Tatjana I., Cathomen, Toni, Mussolino, Claudio
Published in Genes (20.10.2022)
Published in Genes (20.10.2022)
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Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
Turchiano, Giandomenico, Andrieux, Geoffroy, Klermund, Julia, Blattner, Georges, Pennucci, Valentina, el Gaz, Melina, Monaco, Gianni, Poddar, Sushmita, Mussolino, Claudio, Cornu, Tatjana I., Boerries, Melanie, Cathomen, Toni
Published in Cell stem cell (03.06.2021)
Published in Cell stem cell (03.06.2021)
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Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells
Mlambo, Tafadzwa, Nitsch, Sandra, Hildenbeutel, Markus, Romito, Marianna, Müller, Maximilian, Bossen, Claudia, Diederichs, Sven, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Published in Nucleic acids research (18.05.2018)
Published in Nucleic acids research (18.05.2018)
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On- and off-target effects of paired CRISPR-Cas nickase in primary human cells
Klermund, Julia, Rhiel, Manuel, Kocher, Thomas, Chmielewski, Kay Ole, Bischof, Johannes, Andrieux, Geoffroy, el Gaz, Melina, Hainzl, Stefan, Boerries, Melanie, Cornu, Tatjana I., Koller, Ulrich, Cathomen, Toni
Published in Molecular therapy (01.05.2024)
Published in Molecular therapy (01.05.2024)
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Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy
Marone, Romina, Landmann, Emmanuelle, Devaux, Anna, Lepore, Rosalba, Seyres, Denis, Zuin, Jessica, Burgold, Thomas, Engdahl, Corinne, Capoferri, Giuseppina, Dell'Aglio, Alessandro, Larrue, Clément, Simonetta, Federico, Rositzka, Julia, Rhiel, Manuel, Andrieux, Geoffroy, Gallagher, Danielle N, Schröder, Markus S, Wiederkehr, Amélie, Sinopoli, Alessandro, Do Sacramento, Valentin, Haydn, Anna, Garcia-Prat, Laura, Divsalar, Christopher, Camus, Anna, Xu, Liwen, Bordoli, Lorenza, Schwede, Torsten, Porteus, Matthew, Tamburini, Jérôme, Corn, Jacob E, Cathomen, Toni, Cornu, Tatjana I, Urlinger, Stefanie, Jeker, Lukas T
Published in The Journal of experimental medicine (04.12.2023)
Published in The Journal of experimental medicine (04.12.2023)
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Cells Expressing the RING Finger Z Protein Are Resistant to Arenavirus Infection
CORNU, Tatiana I, FELDMANN, Heinz, DE LA TORRE, Juan Carlos
Published in Journal of Virology (01.03.2004)
Published in Journal of Virology (01.03.2004)
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Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing
Knipping, Friederike, Newby, Gregory A., Eide, Cindy R., McElroy, Amber N., Nielsen, Sarah C., Smith, Kyle, Fang, Yongxing, Cornu, Tatjana I., Costa, Caroline, Gutierrez-Guerrero, Alejandra, Bingea, Samuel P., Feser, Colby J., Steinbeck, Benjamin, Hippen, Keli L., Blazar, Bruce R., McCaffrey, Anton, Mussolino, Claudio, Verhoeyen, Els, Tolar, Jakub, Liu, David R., Osborn, Mark J.
Published in Molecular therapy (05.01.2022)
Published in Molecular therapy (05.01.2022)
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Correction: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
Kögl, Tamara, Chang, Hsin-Fang, Staniek, Julian, Chiang, Samuel C C, Thoulass, Gudrun, Lao, Jessica, Weißert, Kristoffer, Dettmer-Monaco, Viviane, Geiger, Kerstin, Manna, Paul T, Beziat, Vivien, Momenilandi, Mana, Tu, Szu-Min, Keppler, Selina J, Pattu, Varsha, Wolf, Philipp, Kupferschmid, Laurence, Tholen, Stefan, Covill, Laura E, Ebert, Karolina, Straub, Tobias, Groß, Miriam, Gather, Ruth, Engel, Helena, Salzer, Ulrich, Schell, Christoph, Maier, Sarah, Lehmberg, Kai, Cornu, Tatjana I, Pircher, Hanspeter, Shahrooei, Mohammad, Parvaneh, Nima, Elling, Roland, Rizzi, Marta, Bryceson, Yenan T, Ehl, Stephan, Aichele, Peter, Ammann, Sandra
Published in The Journal of experimental medicine (01.07.2024)
Published in The Journal of experimental medicine (01.07.2024)
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Journal Article
Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect
Kögl, Tamara, Chang, Hsin-Fang, Staniek, Julian, Chiang, Samuel C C, Thoulass, Gudrun, Lao, Jessica, Weißert, Kristoffer, Dettmer-Monaco, Viviane, Geiger, Kerstin, Manna, Paul T, Beziat, Vivien, Momenilandi, Mana, Tu, Szu-Min, Keppler, Selina J, Pattu, Varsha, Wolf, Philipp, Kupferschmid, Laurence, Tholen, Stefan, Covill, Laura E, Ebert, Karolina, Straub, Tobias, Groß, Miriam, Gather, Ruth, Engel, Helena, Salzer, Ulrich, Schell, Christoph, Maier, Sarah, Lehmberg, Kai, Cornu, Tatjana I, Pircher, Hanspeter, Shahrooei, Mohammad, Parvaneh, Nima, Elling, Roland, Rizzi, Marta, Bryceson, Yenan T, Ehl, Stephan, Aichele, Peter, Ammann, Sandra
Published in The Journal of experimental medicine (01.07.2024)
Published in The Journal of experimental medicine (01.07.2024)
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