Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6)
Yao, Lianbin, Ramanujulu, Pondy Murugappan, Poulsen, Anders, Ohlson, Sten, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
Published in Bioorganic & medicinal chemistry letters (15.08.2018)
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Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat
Chu-Farseeva, Yu-yi, Mustafa, Nurulhuda, Poulsen, Anders, Tan, Eng Chong, Yen, Jeffrey J.Y., Chng, Wee Joo, Dymock, Brian W.
Published in European journal of medicinal chemistry (05.10.2018)
Published in European journal of medicinal chemistry (05.10.2018)
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Journal Article
Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor
Soumyanarayanan, Uttara, Ramanujulu, Pondy Murugappan, Mustafa, Nurulhuda, Haider, Shozeb, Fang Nee, Adina Huey, Tong, Jie Xin, Tan, Kevin S.W., Chng, Wee Joo, Dymock, Brian W.
Published in European journal of medicinal chemistry (15.12.2019)
Published in European journal of medicinal chemistry (15.12.2019)
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Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131)
See, Cheng Shang, Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Lee, Sang Hyun, Dymock, Brian W.
Published in European journal of medicinal chemistry (05.08.2018)
Published in European journal of medicinal chemistry (05.08.2018)
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Journal Article
Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer
See, Cheng Shang, Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Lee, Sang Hyun, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
Published in Bioorganic & medicinal chemistry letters (15.01.2019)
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SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling
Seah, Kwi Shan, Loh, Jian Yun, Nguyen, Thi Thuy Trang, Tan, Hwei Ling, Hutchinson, Paul E., Lim, Kim Kiat, Dymock, Brian W., Long, Yun Chau, Lee, Edmund Jon Deoon, Shen, Han-Ming, Chen, Ee Sin
Published in Experimental cell research (15.09.2018)
Published in Experimental cell research (15.09.2018)
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Overcoming chloroquine resistance in malaria: Design, synthesis and structure–activity relationships of novel chemoreversal agents
Boudhar, Aicha, Ng, Xiao Wei, Loh, Chiew Yee, Chia, Wan Ni, Tan, Zhi Ming, Nosten, Francois, Dymock, Brian W., Tan, Kevin S.W.
Published in European journal of medicinal chemistry (25.08.2016)
Published in European journal of medicinal chemistry (25.08.2016)
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Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents
Feng, Wei, Novera, Wisna, Peh, Kaye, Neo, Donavan, Ramanujulu, Pondy Murugappan, Moore, Philip K., Deng, Lih-Wen, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Antioxidant kinase inhibitors for LRRK2 Parkinson's disease
Sharan, Priyankan, Angeles, Dario C, Ho, Patrick, Dymock, Brian W, Lim, Kah-Leong, Tan, Eng-King
Published in Parkinsonism & related disorders (01.01.2016)
Published in Parkinsonism & related disorders (01.01.2016)
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DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
East, Stephen P., White, Clara Bantry, Barker, Oliver, Barker, Stephanie, Bennett, James, Brown, David, Boyd, E. Andrew, Brennan, Christopher, Chowdhury, Chandana, Collins, Ian, Convers-Reignier, Emmanuelle, Dymock, Brian W., Fletcher, Rowena, Haydon, David J., Gardiner, Mihaly, Hatcher, Stuart, Ingram, Peter, Lancett, Paul, Mortenson, Paul, Papadopoulos, Konstantinos, Smee, Carol, Thomaides-Brears, Helena B., Tye, Heather, Workman, James, Czaplewski, Lloyd G.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Analysis of Protein Target Interactions of Synthetic Mixtures by Affinity-LC/MS
Singh, Prachi, Madhaiyan, Kalaipriya, Duong-Thi, Minh-Dao, Dymock, Brian W., Ohlson, Sten
Published in SLAS discovery (01.04.2017)
Published in SLAS discovery (01.04.2017)
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Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors
Poulsen, Anders, Williams, Meredith, Nagaraj, Harish Mysore, William, Anthony D., Wang, Haishan, Soh, Chang Kai, Xiong, Zheng Chang, Dymock, Brian
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1
Blanchard, Stéphanie, Soh, Chang Kai, Lee, Chai Ping, Poulsen, Anders, Bonday, Zahid, Goh, Kay Lin, Goh, Kee Chuan, Goh, Miah Kiat, Pasha, Mohammed Khalid, Wang, Haishan, Williams, Meredith, Wood, Jeanette M., Ethirajulu, Kantharaj, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
4-Amino derivatives of the Hsp90 inhibitor CCT018159
Barril, Xavier, Beswick, Mandy C., Collier, Adam, Drysdale, Martin J., Dymock, Brian W., Fink, Alexandra, Grant, Kate, Howes, Robert, Jordan, Allan M., Massey, Andrew, Surgenor, Allan, Wayne, Joanne, Workman, Paul, Wright, Lisa
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening
Lee, Angeline C.-H., Ramanujulu, Pondy Murugappan, Poulsen, Anders, Williams, Meredith, Blanchard, Stéphanie, Ma, Diana M., Bonday, Zahid, Goh, Kay Lin, Goh, Kee Chuan, Goh, Miah Kiat, Wood, Jeanette, Dymock, Brian W.
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity
Ermann, Monika, Riether, Doris, Walker, Edward R., Mushi, Innocent F., Jenkins, James E., Noya-Marino, Beatriz, Brewer, Mark L., Taylor, Malcolm G., Amouzegh, Patricia, East, Stephen P., Dymock, Brian W., Gemkow, Mark J., Kahrs, Andreas F., Ebneth, Andreas, Löbbe, Sabine, O’Shea, Kathy, Shih, Daw-Tsun, Thomson, David
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures
Dymock, Brian, Barril, Xavier, Beswick, Mandy, Collier, Adam, Davies, Nicholas, Drysdale, Martin, Fink, Alexandra, Fromont, Christophe, Hubbard, Roderick E., Massey, Andrew, Surgenor, Allan, Wright, Lisa
Published in Bioorganic & medicinal chemistry letters (2004)
Published in Bioorganic & medicinal chemistry letters (2004)
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