Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors
Fidanze, Steven D., Liu, Dachun, Mantei, Robert A., Hasvold, Lisa A., Pratt, John K., Sheppard, George S., Wang, Le, Holms, James H., Dai, Yujia, Aguirre, Ana, Bogdan, Andrew, Dietrich, Justin D., Marjanovic, Jasmina, Park, Chang H., Hutchins, Charles W., Lin, Xiaoyu, Bui, Mai H., Huang, Xiaoli, Wilcox, Denise, Li, Leiming, Wang, Rongqi, Kovar, Peter, Magoc, Terrance J., Rajaraman, Ganesh, Albert, Daniel H., Shen, Yu, Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Methylpyrrole inhibitors of BET bromodomains
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
Published in Bioorganic & medicinal chemistry letters (15.05.2017)
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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
WANG, Gary T, MANTEI, Robert A, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, HUBBARD, Robert D, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora, XIAOMING HU, KOVAR, Peter, JOHNSON, Eric F, OSTERLING, Donald J
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties
Kawai, Megumi, BaMaung, Nwe Y., Fidanze, Steve D., Erickson, Scott A., Tedrow, Jason S., Sanders, William J., Vasudevan, Anil, Park, Chang, Hutchins, Charles, Comess, Kenneth M., Kalvin, Douglas, Wang, Jieyi, Zhang, Qian, Lou, Pingping, Tucker-Garcia, Lora, Bouska, Jennifer, Bell, Randy L., Lesniewski, Richard, Henkin, Jack, Sheppard, George S.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases
HUBBARD, Robert D, BAMAUNG, Nwe Y, OSTERLING, Donald J, JOHNSON, Eric F, BOUSKA, Jennifer, JIEYI WANG, DAVIDSEN, Steven K, BELL, Randy L, SHEPPARD, George S, FIDANZE, Steve D, ERICKSON, Scott A, PALAZZO, Fabio, WILSBACHER, Julie L, QIAN ZHANG, TUCKER, Lora A, XIAOMING HU, KOVAR, Peter
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Pyrazolo[3,4- d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR)
Hubbard, Robert D., Bamaung, Nwe Y., Palazzo, Fabio, Zhang, Qian, Kovar, Peter, Osterling, Donald J., Hu, Xiaoming, Wilsbacher, Julie L., Johnson, Eric F., Bouska, Jennifer, Wang, Jieyi, Bell, Randy L., Davidsen, Steven K., Sheppard, George S.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2
SHEPPARD, George S, JIEYI WANG, PINGPING LOU, CHANG PARK, KIM, Ki H, HENKIN, Jack, LESNIEWSKI, Richard, KAWAI, Megumi, BAMAUNG, Nwe Y, CRAIG, Richard A, ERICKSON, Scott A, LYNCH, Linda, PATEL, Jyoti, FAN YANG, SEARLE, Xenia B
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Wang, Gary T., Mantei, Robert A., Kawai, Megumi, Tedrow, Jason S., Barnes, David M., Wang, Jieyi, Zhang, Qian, Lou, Pingping, Garcia, Lora A., Bouska, Jennifer, Yates, Melinda, Park, Chang, Judge, Russell A., Lesniewski, Richard, Sheppard, George S., Bell, Randy L.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Lysyl 4-aminobenzoic acid derivatives as potent small molecule mimetics of plasminogen kringle 5
SHEPPARD, George S, KAWAI, Megumi, CRAIG, Richard A, DAVIDSON, Donald J, MAJEST, Sandra M, BELL, Randy L, HENKIN, Jack
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonist
Albert, Daniel H., Magoc, Terrance J., Tapang, Paul, Luo, Gongjin, Morgan, Douglas W., Curtin, Michael, Sheppard, George S., Xu, Lianhong, Heyman, H.Robin, Davidsen, Steven K., Summers, James B., Carter, George W.
Published in European journal of pharmacology (23.04.1997)
Published in European journal of pharmacology (23.04.1997)
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Journal Article
Methylpyrrole inhibitors of BET bromodomains
Hasvold, Lisa A., Sheppard, George S., Wang, Le, Fidanze, Steven D., Liu, Dachun, Pratt, John K., Mantei, Robert A., Wada, Carol K., Hubbard, Robbert, Shen, Yu, Lin, Xiaoyu, Huang, Xiaoli, Warder, Scott E., Wilcox, Denise, Li, Leiming, Buchanan, F. Greg, Smithee, Lauren, Albert, Daniel H., Magoc, Terrance J., Park, Chang H., Petros, Andrew M., Panchal, Sanjay C., Sun, Chaohong, Kovar, Peter, Soni, Nirupama B., Elmore, Steven W., Kati, Warren M., McDaniel, Keith F.
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
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Published in Bioorganic & medicinal chemistry letters (01.05.2017)
Journal Article
Substituted 4-amino-1 H-pyrazolo[3,4- d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
Wang, Gary T., Mantei, Robert A., Hubbard, Robert D., Wilsbacher, Julie L., Zhang, Qian, Tucker, Lora, Hu, Xiaoming, Kovar, Peter, Johnson, Eric F., Osterling, Donald J., Bouska, Jennifer, Wang, Jieyi, Davidsen, Steven K., Bell, Randy L., Sheppard, George S.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Why optimize cancer drugs for ADMET?
Sheppard, George S., Bouska, Jennifer J.
Published in Drug discovery today. Therapeutic strategies (2005)
Published in Drug discovery today. Therapeutic strategies (2005)
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Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors
Sheppard, George S., Florjancic, Alan S., Giesler, Jamie R., Xu, Lianhong, Guo, Yan, Davidsen, Steven K., Marcotte, Patrick A., Elmore, Ildiko, Albert, Daniel H., Magoc, Terrance J., Bouska, Jennifer J., Goodfellow, Carole L., Morgan, Douglas W., Summers, James B.
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
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Synthesis and evaluation of water soluble indole pyrrolothiazole paf antagonists
Sheppard, George S., Davidsen, Steven K., Carrera, George M., Pireh, Daisy, Holms, James H., Robin Heyman, H., Steinman, Douglas H., Curtin, Michael L., Conway, Richard G., Rhein, David A., Albert, Daniel H., Tapang, Paul, Magoc, Terrance J., Summers, James B.
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
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Journal Article
Discovery and optimization of indole pyrrolothiazole paf antagonists
Holms, James H., Davidsen, Steven K., Sheppard, George S., Carrera, George M., Curtin, Nichael L., Heyman, H.Robin, Pireh, Daisy, Steinman, Douglas H., Albert, Daniel H., Conway, Richard G., Luo, Gongjin, Magoc, Terrance J., Tapang, Paul, Rhein, David A., Summers, James B.
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
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Journal Article
5120749 Platelet activating antagonists
Summers, James B, Sheppard, George S, Phillips, James G, Pireh, Daisy, Steinman, Douglas H, May, Paul D
Published in Transfusion science (1993)
Published in Transfusion science (1993)
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