A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis
Yoon, Sung-Hee, Meyer, Mark B, Arevalo, Carlos, Tekguc, Murat, Zhang, Chengcheng, Wang, Jialiang S, Castro Andrade, Christian D, Strauss, Katelyn, Sato, Tadatoshi, Benkusky, Nancy A, Lee, Seong Min, Berdeaux, Rebecca, Foretz, Marc, Sundberg, Thomas B, Xavier, Ramnik J, Adelmann, Charles H, Brooks, Daniel J, Anselmo, Anthony, Sadreyev, Ruslan I, Rosales, Ivy A, Fisher, David E, Gupta, Navin, Morizane, Ryuji, Greka, Anna, Pike, J Wesley, Mannstadt, Michael, Wein, Marc N
Published in The Journal of clinical investigation (01.05.2023)
Published in The Journal of clinical investigation (01.05.2023)
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SIKs control osteocyte responses to parathyroid hormone
Wein, Marc N., Liang, Yanke, Goransson, Olga, Sundberg, Thomas B., Wang, Jinhua, Williams, Elizabeth A., O’Meara, Maureen J., Govea, Nicolas, Beqo, Belinda, Nishimori, Shigeki, Nagano, Kenichi, Brooks, Daniel J., Martins, Janaina S., Corbin, Braden, Anselmo, Anthony, Sadreyev, Ruslan, Wu, Joy Y., Sakamoto, Kei, Foretz, Marc, Xavier, Ramnik J., Baron, Roland, Bouxsein, Mary L., Gardella, Thomas J., Divieti-Pajevic, Paola, Gray, Nathanael S., Kronenberg, Henry M.
Published in Nature communications (19.10.2016)
Published in Nature communications (19.10.2016)
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
Sundberg, Thomas B., Choi, Hwan Geun, Song, Joo-Hye, Russell, Caitlin N., Hussain, Mahmud M., Graham, Daniel B., Khor, Bernard, Gagnon, John, O'Connell, Daniel J., Narayan, Kavitha, Dančik, Vlado, Perez, Jose R., Reinecker, Hans-Christian, Gray, Nathanael S., Schreiber, Stuart L., Xavier, Ramnik J., Shamji, Alykhan F.
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Babbe, Holger, Sundberg, Thomas B, Tichenor, Mark, Seierstad, Mark, Bacani, Genesis, Berstler, James, Chai, Wenying, Chang, Leon, Chung, De Michael, Coe, Kevin, Collins, Bernard, Finley, Michael, Guletsky, Alexander, Lemke, Christopher T, Mak, Puiying A, Mathur, Ashok, Mercado-Marin, Eduardo V, Metkar, Shailesh, Raymond, Donald D, Rives, Marie-Laure, Rizzolio, Michele, Shaffer, Paul L, Smith, Russell, Smith, Jacqueline, Steele, Ruth, Steffens, Helena, Suarez, Javier, Tian, Gaochao, Majewski, Nathan, Volak, Laurie P, Wei, Jianmei, Desai, Prerak T, Ong, Luvena L, Koudriakova, Tatiana, Goldberg, Steven D, Hirst, Gavin, Kaushik, Virendar K, Ort, Tatiana, Seth, Nilufer, Graham, Daniel B, Plevy, Scott, Venable, Jennifer D, Xavier, Ramnik J, Towne, Jennifer E
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
Tang, Cheng-Chia, Castro Andrade, Christian D, O'Meara, Maureen J, Yoon, Sung-Hee, Sato, Tadatoshi, Brooks, Daniel J, Bouxsein, Mary L, Martins, Janaina da Silva, Wang, Jinhua, Gray, Nathanael S, Misof, Barbara, Roschger, Paul, Blouin, Stephane, Klaushofer, Klaus, Velduis-Vlug, Annegreet, Vegting, Yosta, Rosen, Clifford J, O'Connell, Daniel, Sundberg, Thomas B, Xavier, Ramnik J, Ung, Peter, Schlessinger, Avner, Kronenberg, Henry M, Berdeaux, Rebecca, Foretz, Marc, Wein, Marc N
Published in eLife (23.06.2021)
Published in eLife (23.06.2021)
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The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway
Arnett, Azlann, Moo, Keagan G., Flynn, Kaitlin J., Sundberg, Thomas B., Johannessen, Liv, Shamji, Alykhan F., Gray, Nathanael S., Decker, Thomas, Zheng, Ye, Gersuk, Vivian H., Rahman, Ziaur S., Levy, David E., Marié, Isabelle J., Linsley, Peter S., Xavier, Ramnik J., Khor, Bernard
Published in Molecular and cellular biology (24.08.2021)
Published in Molecular and cellular biology (24.08.2021)
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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
Khor, Bernard, Gagnon, John D, Goel, Gautam, Roche, Marly I, Conway, Kara L, Tran, Khoa, Aldrich, Leslie N, Sundberg, Thomas B, Paterson, Alison M, Mordecai, Scott, Dombkowski, David, Schirmer, Melanie, Tan, Pauline H, Bhan, Atul K, Roychoudhuri, Rahul, Restifo, Nicholas P, O'Shea, John J, Medoff, Benjamin D, Shamji, Alykhan F, Schreiber, Stuart L, Sharpe, Arlene H, Shaw, Stanley Y, Xavier, Ramnik J
Published in eLife (22.05.2015)
Published in eLife (22.05.2015)
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Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing
O’Connell, Daniel J., Kolde, Raivo, Sooknah, Matthew, Graham, Daniel B., Sundberg, Thomas B., Latorre, Isabel J., Mikkelsen, Tarjei S., Xavier, Ramnik J.
Published in Cell systems (25.05.2016)
Published in Cell systems (25.05.2016)
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Corrigendum: SIKs control osteocyte responses to parathyroid hormone
Wein, Marc N, Liang, Yanke, Goransson, Olga, Sundberg, Thomas B, Wang, Jinhua, Williams, Elizabeth A, O'Meara, Maureen J, Govea, Nicolas, Beqo, Belinda, Nishimori, Shigeki, Nagano, Kenichi, Brooks, Daniel J, Martins, Janaina S, Corbin, Braden, Anselmo, Anthony, Sadreyev, Ruslan, Wu, Joy Y, Sakamoto, Kei, Foretz, Marc, Xavier, Ramnik J, Baron, Roland, Bouxsein, Mary L, Gardella, Thomas J, Divieti-Pajevic, Paola, Gray, Nathanael S, Kronenberg, Henry M
Published in Nature communications (22.02.2017)
Published in Nature communications (22.02.2017)
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Apoptotic Signaling Activated by Modulation of the F0F1-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes
Sundberg, Thomas B, Swenson, Lara, Wahl, Daniel R, Opipari, Jr, Anthony W, Glick, Gary D
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
Bhagavathula, Narasimharao, Nerusu, Kamalakar C, Hanosh, Andrew, Aslam, Muhammad N, Sundberg, Thomas B, Opipari, Jr, Anthony W, Johnson, Kent, Kang, Sewon, Glick, Gary D, Varani, James
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation
SUNDBERG, Thomas B, NEY, Gina M, SUBRAMANIAN, Chitra, OPIPARI, Anthony W, GLICK, Gary D
Published in Cancer research (Chicago, Ill.) (01.02.2006)
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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Correction: Corrigendum: SIKs control osteocyte responses to parathyroid hormone
Wein, Marc N., Liang, Yanke, Goransson, Olga, Sundberg, Thomas B., Wang, Jinhua, Williams, Elizabeth A., O’Meara, Maureen J., Govea, Nicolas, Beqo, Belinda, Nishimori, Shigeki, Nagano, Kenichi, Brooks, Daniel J., Martins, Janaina S., Corbin, Braden, Anselmo, Anthony, Sadreyev, Ruslan, Wu, Joy Y., Sakamoto, Kei, Foretz, Marc, Xavier, Ramnik J., Baron, Roland, Bouxsein, Mary L., Gardella, Thomas J., Divieti-Pajevic, Paola, Gray, Nathanael S., Kronenberg, Henry M.
Published in Nature communications (22.02.2017)
Published in Nature communications (22.02.2017)
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Disruption of Wnt Planar Cell Polarity Signaling by Aberrant Accumulation of the MetAP-2 Substrate Rab37
Sundberg, Thomas B., Darricarrere, Nicole, Cirone, Pasquale, Li, Xia, McDonald, Lucy, Mei, Xue, Westlake, Christopher J., Slusarski, Diane C., Beynon, Robert J., Crews, Craig M.
Published in Chemistry & biology (28.10.2011)
Published in Chemistry & biology (28.10.2011)
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Journal Article
Apoptotic Signaling Activated by Modulation of the F 0 F 1 -ATPase: Implications for Selective Killing of Autoimmune Lymphocytes
Sundberg, Thomas B., Swenson, Lara, Wahl, Daniel R., Opipari, Anthony W., Glick, Gary D.
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2009)
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Journal Article
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1 H -benzo[b][1,4]diazepin-2(3 H )-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
Bhagavathula, Narasimharao, Nerusu, Kamalakar C., Hanosh, Andrew, Aslam, Muhammad N., Sundberg, Thomas B., Opipari, Anthony W., Johnson, Kent, Kang, Sewon, Glick, Gary D., Varani, James
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2008)
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Journal Article