CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors
Vora, Sadhna R., Juric, Dejan, Kim, Nayoon, Mino-Kenudson, Mari, Huynh, Tiffany, Costa, Carlotta, Lockerman, Elizabeth L., Pollack, Sarah F., Liu, Manway, Li, Xiaoyan, Lehar, Joseph, Wiesmann, Marion, Wartmann, Markus, Chen, Yan, Cao, Z. Alexander, Pinzon-Ortiz, Maria, Kim, Sunkyu, Schlegel, Robert, Huang, Alan, Engelman, Jeffrey A.
Published in Cancer cell (14.07.2014)
Published in Cancer cell (14.07.2014)
Get full text
Journal Article
A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models
Brown, Jeffrey L, Cao, Z Alexander, Pinzon-Ortiz, Maria, Kendrew, Jane, Reimer, Corinne, Wen, Shenghua, Zhou, Joe Q, Tabrizi, Mohammad, Emery, Steve, McDermott, Brenda, Pablo, Lourdes, McCoon, Patricia, Bedian, Vahe, Blakey, David C
Published in Molecular cancer therapeutics (01.01.2010)
Published in Molecular cancer therapeutics (01.01.2010)
Get full text
Journal Article
RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth
Nyfeler, Beat, Chen, Yan, Li, Xiaoyan, Pinzon-Ortiz, Maria, Wang, Zuncai, Reddy, Anupama, Pradhan, Elina, Das, Rita, Lehár, Joseph, Schlegel, Robert, Finan, Peter M, Cao, Z Alexander, Murphy, Leon O, Huang, Alan
Published in PloS one (14.11.2012)
Published in PloS one (14.11.2012)
Get full text
Journal Article
The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane
Nagar, Rupa, Garcia Castillo, Stefano S., Pinzon-Ortiz, Maria, Patray, Sharon, Coppi, Alida, Kanatani, Sachie, Moritz, Robert L., Swearingen, Kristian E., Ferguson, Michael A.J., Sinnis, Photini
Published in The Journal of biological chemistry (01.08.2024)
Published in The Journal of biological chemistry (01.08.2024)
Get full text
Journal Article
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade
Sehgal, Kartik, Portell, Andrew, Ivanova, Elena V, Lizotte, Patrick H, Mahadevan, Navin R, Greene, Jonathan R, Vajdi, Amir, Gurjao, Carino, Teceno, Tyler, Taus, Luke J, Thai, Tran C, Kitajima, Shunsuke, Liu, Derek, Tani, Tetsuo, Noureddine, Moataz, Lau, Christie J, Kirschmeier, Paul T, Liu, David, Giannakis, Marios, Jenkins, Russell W, Gokhale, Prafulla C, Goldoni, Silvia, Pinzon-Ortiz, Maria, Hastings, William D, Hammerman, Peter S, Miret, Juan J, Paweletz, Cloud P, Barbie, David A
Published in The Journal of clinical investigation (19.01.2021)
Published in The Journal of clinical investigation (19.01.2021)
Get full text
Journal Article
Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms
Rampal, Raajit K, Pinzon-Ortiz, Maria, Somasundara, Amritha Varshini Hanasoge, Durham, Benjamin, Koche, Richard, Spitzer, Barbara, Mowla, Shoron, Krishnan, Aishwarya, Li, Bing, An, Wenbin, Derkach, Andriy, Devlin, Sean, Rong, Xianhui, Longmire, Tyler, Eisman, Shira Esther, Cordner, Keith, Whitfield, Justin T, Vanasse, Gary, Cao, Zhu A, Levine, Ross L
Published in Clinical cancer research (15.06.2021)
Published in Clinical cancer research (15.06.2021)
Get full text
Journal Article
Abstract 3489: Novel translational pharmacology approaches on dose reduction and alternative scheduling for the combination of JAK inhibitor, ruxolitinib, PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011 in a preclinical model of myeloproliferative neoplasia
Pinzon-Ortiz, Maria, Rong, Xianhui, Vanasse, Gary, Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models
Kim, Sunkyu, Tiedt, Ralph, Loo, Alice, Horn, Thomas, Delach, Scott, Kovats, Steven, Haas, Kristy, Engstler, Barbara Schacher, Cao, Alexander, Pinzon-Ortiz, Maria, Mulford, Iain, Acker, Michael G, Chopra, Rajiv, Brain, Christopher, di Tomaso, Emmanuelle, Sellers, William R, Caponigro, Giordano
Published in Oncotarget (16.10.2018)
Published in Oncotarget (16.10.2018)
Get full text
Journal Article
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation
Wong, Gwendolyn T., Manfra, Denise, Poulet, Frederique M., Zhang, Qi, Josien, Hubert, Bara, Thomas, Engstrom, Laura, Pinzon-Ortiz, Maria, Fine, Jay S., Lee, Hu-Jung J., Zhang, Lili, Higgins, Guy A., Parker, Eric M.
Published in The Journal of biological chemistry (26.03.2004)
Published in The Journal of biological chemistry (26.03.2004)
Get full text
Journal Article
Abstract 3684: The combination of JAK inhibitor, ruxolitinib, pan-PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011, in a preclinical mouse model of myeloproliferative neoplasia
Pinzon-Ortiz, Maria, Rong, Xianhui, Saci, Abdel, Schlegel, Robert, Vanasse, Gary, Caponigro, Giordano, Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract LB-237: Targeting HER3 and IGF1R in NRG1 high lung squamous cell carcinoma
Sheng, Qing, Pinzon-Ortiz, Maria, Das, Rita, Huang, Alan, Rong, Xianhui, Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract 2522: Molecular and cellular mechanisms underlying the therapeutic efficacy of the combination of JAK inhibitor, ruxolitinib, PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011, in a preclinical model of myeloproliferative neoplasia
Pinzon-Ortiz, Maria, Longmire, Tyler, Rong, Xianhui, Caponigro, Giordano, Vanasse, Gary, Lee, Benjamin H., Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 782: Modulation of receptor tyrosine kinase signaling by cMET inhibitor, INC280, in cMETmut/amp gastric carcinoma cell line Hs746.T
Pinzon-Ortiz, Maria C., Rong, Xianhui, Liang, Jinsheng, Wang, Hui Qin, Huang, Alan, Schlegel, Robert, Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 2343: The immune modulatory roles of IAP inhibitor, LCL161, and its connection to immune-checkpoint molecules
Pinzon-Ortiz, Maria, Hastings, William, Longmire, Tyler, Shaw, Pamela, Rong, Xianhui, Murakami, Masato, Lee, Benjamin H., Dranoff, Glenn, MacIsaac, Kenzie, Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Correction: The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models
Kim, Sunkyu, Tiedt, Ralph, Loo, Alice, Horn, Thomas, Delach, Scott, Kovats, Steven, Haas, Kristy, Engstler, Barbara Schacher, Cao, Alexander, Pinzon-Ortiz, Maria, Mulford, Iain, Acker, Michael G, Chopra, Rajiv, Brain, Christopher, Tomaso, Emmanuelle di, Sellers, William R, Caponigro, Giordano
Published in Oncotarget (07.04.2020)
Published in Oncotarget (07.04.2020)
Get full text
Journal Article
Abstract 2692: High allele frequency of KRAS functional mutations predicts resistance to MEK inhibitors: Evidence from cell lines and human tumor xenograft models
Reddy, Anupama, Pinzon-Ortiz, Maria, Derti, Adnan, Korn, Joshua, Ruddy, David, Yang, Guizhi, Green, John, Gao, Hui, Lehar, Joseph, Caponigro, Giordano, Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 3683: Targeting PIK3CA mutant breast cancer with the combination of PIK3CA-specific inhibitor, BYL719, and IGF1-R antibody, ganitumab
Cao, Z. Alexander, Pinzon-Ortiz, Maria, Chen, Yan, Li, Xiaoyan, Beltran, Pedro J., Gansert, Jennifer, Peters, Malte, Schlegel, Robert, Schumacher, Karl M., Huang, Alan
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract 1066: Combination synergy of JAK inhibitor, BVB808, and FGFR inhibitor, BGJ398, in an FGFR3-driven multiple myeloma model
Pinzon-Ortiz, Maria, Tan, Lujian, Yao, Yao, Schlegel, Robert, Radimerski, Thomas, Cao, Z. Alexander
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Get full text
Journal Article