Biomimetic Synthesis of (−)-Longithorone A
Layton, Mark E, Morales, Carl A, Shair, Matthew D
Published in Journal of the American Chemical Society (06.02.2002)
Published in Journal of the American Chemical Society (06.02.2002)
Get full text
Journal Article
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
Layton, Mark E., Kern, Jeffrey C., Hartingh, Timothy J., Shipe, William D., Raheem, Izzat, Kandebo, Monika, Hayes, Robert P., Huszar, Sarah, Eddins, Donnie, Ma, Bennett, Fuerst, Joy, Wollenberg, Gordon K., Li, Jing, Fritzen, Jeff, McGaughey, Georgia B., Uslaner, Jason M., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.
Published in Journal of medicinal chemistry (26.01.2023)
Published in Journal of medicinal chemistry (26.01.2023)
Get full text
Journal Article
Synthesis of Cyclooctenones Using Intramolecular Hydroacylation
Aloise, Allen D, Layton, Mark E, Shair, Matthew D
Published in Journal of the American Chemical Society (20.12.2000)
Published in Journal of the American Chemical Society (20.12.2000)
Get full text
Journal Article
Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists
Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.
Published in ACS chemical neuroscience (20.07.2011)
Published in ACS chemical neuroscience (20.07.2011)
Get full text
Journal Article
Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
Get full text
Journal Article
Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile
Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P. J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
Get full text
Journal Article
Discovery of Arylsulfonamide Na v 1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile
Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, 3rd, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
Get full text
Journal Article
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI
Pero, Joseph E, Rossi, Michael A, Kelly, Michael J, Lehman, Hannah D. G. F, Layton, Mark E, Garbaccio, Robert M, O’Brien, Julie A, Magliaro, Brian C, Uslaner, Jason M, Huszar, Sarah L, Fillgrove, Kerry L, Tang, Cuyue, Kuo, Yuhsin, Joyce, Leo A, Sherer, Edward C, Jacobson, Marlene A
Published in ACS medicinal chemistry letters (10.03.2016)
Published in ACS medicinal chemistry letters (10.03.2016)
Get full text
Journal Article
Synthesis of (+)-CP-263,114
Chen, Chuo, Layton, Mark E, Sheehan, Scott M, Shair, Matthew D
Published in Journal of the American Chemical Society (02.08.2000)
Published in Journal of the American Chemical Society (02.08.2000)
Get full text
Journal Article
Stereospecific Synthesis of the CP-263,114 Core Structure
Chen, Chuo, Layton, Mark E, Shair, Matthew D
Published in Journal of the American Chemical Society (21.10.1998)
Published in Journal of the American Chemical Society (21.10.1998)
Get full text
Journal Article
Discovery of Arylsulfonamide Na(v)1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile
Roecker, Anthony J., Layton, Mark E., Pero, Joseph E., Kelly, Michael J., Greshock, Thomas J., Kraus, Richard L., Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E., Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P. J., Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K., Burgey, Christopher S.
Published in ACS medicinal chemistry letters (10.06.2021)
Published in ACS medicinal chemistry letters (10.06.2021)
Get full text
Journal Article