From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
Petrilli, Whitney L., Adam, Gregory C., Erdmann, Roman S., Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P., Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M., Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P., Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M., Strack, Alison M., Youm, Hyewon, Zhao, Kake, Zink, Deborah L., Zokian, Hratch, Addona, George H., Akinsanya, Karen, Tata, James R., Xiong, Yusheng, Imbriglio, Jason E.
Published in Cell chemical biology (16.01.2020)
Published in Cell chemical biology (16.01.2020)
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Journal Article
Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity
Jayasuriya, Hiranthi, Herath, Kithsiri B., Zhang, Chaowei, Zink, Deborah L., Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Gonzalez, Ignacio, Salazar, Oscar, Pelaez, Fernando, Cummings, Richard, Ha, Sookhee, Wang, Jun, Singh, Sheo B.
Published in Angewandte Chemie (International ed.) (01.01.2007)
Published in Angewandte Chemie (International ed.) (01.01.2007)
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Journal Article
Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy
Singh, Sheo B, Jayasuriya, Hiranthi, Ondeyka, John G, Herath, Kithsiri B, Zhang, Chaowei, Zink, Deborah L, Tsou, Nancy N, Ball, Richard G, Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Pelaez, Fernando, Young, Katherine, Wang, Jun
Published in Journal of the American Chemical Society (13.09.2006)
Published in Journal of the American Chemical Society (13.09.2006)
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Journal Article
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
Petrilli, Whitney L, Adam, Gregory C, Erdmann, Roman S, Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P, Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M, Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P, Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M, Strack, AlisonM, Youm, Hyewon, Zhao, Kake, Zink, Deborah L, Zokian, Hratch, Addona, George H, Akinsanya, Karen, Tata, James R, Xiong, Yusheng, Imbriglio, Jason E
Published in Cell chemical biology (18.02.2021)
Published in Cell chemical biology (18.02.2021)
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Journal Article
Platensimycin and Platencin Congeners from Streptomyces platensis
Zhang, Chaowei, Ondeyka, John, Herath, Kithsiri, Jayasuriya, Hiranthi, Guan, Ziqiang, Zink, Deborah L, Dietrich, Lisa, Burgess, Bruce, Ha, Sookhee N, Wang, Jun, Singh, Sheo B
Published in Journal of natural products (Washington, D.C.) (25.03.2011)
Published in Journal of natural products (Washington, D.C.) (25.03.2011)
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Journal Article
Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin
Ondeyka, John G, Smith, Scott K, Zink, Deborah L, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Polishook, Jon D, Garlisi, Charles, Mcguinness, Debra, Smith, Elizabeth, Qiu, Hongchen, Gill, Charles J, Donald, Robert GK, Phillips, John W, Goetz, Michael A, Singh, Sheo B
Published in Journal of antibiotics (01.07.2014)
Published in Journal of antibiotics (01.07.2014)
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Journal Article
Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis
Zhang, Chaowei, Ondeyka, John, Zink, Deborah L, Burgess, Bruce, Wang, Jun, Singh, Sheo B
Published in Chemical communications (Cambridge, England) (28.10.2008)
Published in Chemical communications (Cambridge, England) (28.10.2008)
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Journal Article
In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors
Salowe, Scott P, Zhang, Lei, Zokian, Hratch J, Gesell, Jennifer J, Zink, Deborah L, Wiltsie, Judyann, Ai, Xi, Kavana, Michael, Pinto, Shirly
Published in Journal of biomolecular screening (01.12.2016)
Published in Journal of biomolecular screening (01.12.2016)
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Journal Article
Isolation, Structure Elucidation, and Biological Activity of Altersolanol P Using Staphylococcus aureus Fitness Test Based Genome-Wide Screening
Ondeyka, John, Buevich, Alexei V, Williamson, R. Thomas, Zink, Deborah L, Polishook, Jon D, Occi, James, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Donald, Robert G. K, Phillips, John W, Goetz, Michael A, Singh, Sheo B
Published in Journal of natural products (Washington, D.C.) (28.03.2014)
Published in Journal of natural products (Washington, D.C.) (28.03.2014)
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Journal Article
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities
Singh, Sheo B., Goetz, Michael A., Smith, Scott K., Zink, Deborah L., Polishook, Jon, Onishi, Russell, Salowe, Scott, Wiltsie, Judyann, Allocco, John, Sigmund, Janet, Dorso, Karen, de la Cruz, Mercedes, Martín, Jesús, Vicente, Francisca, Genilloud, Olga, Donald, Robert G.K., Phillips, John W.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Journal Article
Isolation, Structure, and Antibacterial Activity of Philipimycin, A Thiazolyl Peptide Discovered from Actinoplanes philippinensis MA7347
Zhang, Chaowei, Occi, James, Masurekar, Prakash, Barrett, John F, Zink, Deborah L, Smith, Scott, Onishi, Russell, Ha, Sookhee, Salazar, Oscar, Genilloud, Olga, Basilio, Angela, Vicente, Francisca, Gill, Charles, Hickey, Emily J, Dorso, Karen, Motyl, Mary, Singh, Sheo B
Published in Journal of the American Chemical Society (10.09.2008)
Published in Journal of the American Chemical Society (10.09.2008)
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Journal Article
Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (Capnodium sp.)
Herath, Kithsiri, Jayasuriya, Hiranthi, Zink, Deborah L, Sigmund, Jan, Vicente, Francisca, de la Cruz, Mercedes, Basilio, Angela, Bills, Gerald F, Polishook, Jon D, Donald, Robert, Phillips, John, Goetz, Michael, Singh, Sheo B
Published in Journal of natural products (Washington, D.C.) (23.03.2012)
Published in Journal of natural products (Washington, D.C.) (23.03.2012)
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Journal Article
Structure and Semisynthesis of Platensimide A, Produced by Streptomyces platensis
Herath, Kithsiri B, Zhang, Chaowei, Jayasuriya, Hiranthi, Ondeyka, John G, Zink, Deborah L, Burgess, Bruce, Wang, Jun, Singh, Sheo B
Published in Organic letters (01.05.2008)
Published in Organic letters (01.05.2008)
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Journal Article
Anthelmintic constituents of Clonostachys candelabrum
Ayers, Sloan, Zink, Deborah L, Mohn, Kenneth, Powell, Joanne S, Brown, Christine M, Bills, Gerald, Grund, Alan, Thompson, Donald, Singh, Sheo B
Published in Journal of antibiotics (01.03.2010)
Published in Journal of antibiotics (01.03.2010)
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Journal Article
Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness Test
Xu, Deming, Ondeyka, John, Harris, Guy H, Zink, Deborah, Kahn, Jennifer Nielsen, Wang, Hao, Bills, Gerald, Platas, Gonzalo, Wang, Wenxian, Szewczak, Alexander A, Liberator, Paul, Roemer, Terry, Singh, Sheo B
Published in Journal of natural products (Washington, D.C.) (26.08.2011)
Published in Journal of natural products (Washington, D.C.) (26.08.2011)
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Journal Article
Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening
Singh, Sheo B, Zhang, Chaowei, Zink, Deborah L, Herath, Kithsiri, Ondeyka, John, Masurekar, Prakash, Jayasuriya, Hiranthi, Goetz, Michael A, Tormo, Jose Rubén, Vicente, Francisca, Martín, Jesús, González, Ignacio, Genilloud, Olga
Published in Journal of antibiotics (01.10.2013)
Published in Journal of antibiotics (01.10.2013)
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Journal Article
Thiazomycins, Thiazolyl Peptide Antibiotics from Amycolatopsis fastidiosa
Zhang, Chaowei, Herath, Kithsiri, Jayasuriya, Hiranthi, Ondeyka, John G, Zink, Deborah L, Occi, James, Birdsall, Gwyneth, Venugopal, Jayashree, Ushio, Misti, Burgess, Bruce, Masurekar, Prakash, Barrett, John F, Singh, Sheo B
Published in Journal of natural products (Washington, D.C.) (22.05.2009)
Published in Journal of natural products (Washington, D.C.) (22.05.2009)
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Journal Article
Isolation, enzyme-bound structure and antibacterial activity of platencin from Streptomyces platensis
SINGH, Sheo B, ONDEYKA, John G, HERATH, Kithsiri B, CHAOWEI ZHANG, JAYASURIYA, Hiranthi, ZINK, Deborah L, PARTHASARATHY, Gopalakrishnan, BECKER, Joseph W, JUN WANG, SOISSON, Stephen M
Published in Bioorganic & medicinal chemistry letters (03.09.2010)
Published in Bioorganic & medicinal chemistry letters (03.09.2010)
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Journal Article
Discovery and antibacterial activity of glabramycin A–C from Neosartorya glabra by an antisense strategy
Jayasuriya, Hiranthi, Zink, Deborah, Basilio, Angela, Vicente, Francisca, Collado, Javier, Bills, Gerald, Goldman, Mary Lee, Motyl, Mary, Huber, Joann, Dezeny, Gabe, Byrne, Kevin, Singh, Sheo B
Published in Journal of antibiotics (01.05.2009)
Published in Journal of antibiotics (01.05.2009)
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Journal Article
Isolation, Structure, and Antibacterial Activities of Lucensimycins D−G, Discovered from Streptomyces lucensis MA7349 Using an Antisense Strategy
Singh, Sheo B, Zink, Deborah L, Dorso, Karen, Motyl, Mary, Salazar, Oscar, Basilio, Angela, Vicente, Francisca, Byrne, Kevin M, Ha, Sookhee, Genilloud, Olga
Published in Journal of natural products (Washington, D.C.) (27.03.2009)
Published in Journal of natural products (Washington, D.C.) (27.03.2009)
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