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Published in Biochemical journal (01.10.2005)
Published in Biochemical journal (01.10.2005)
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Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1
Bernardo, Paul H., Sivaraman, Thirunavukkarasu, Wan, Kah-Fei, Xu, Jin, Krishnamoorthy, Janarthanan, Song, Chun Meng, Tian, Liming, Chin, Jasmine S. F., Lim, Diane S. W., Mok, Henry Y. K., Yu, Victor C., Tong, Joo Chuan, Chai, Christina L. L.
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Published in Pure and applied chemistry (05.02.2011)
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Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
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Published in PLoS pathogens (01.08.2016)
Published in PLoS pathogens (01.08.2016)
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Discovery of Dengue Virus NS4B Inhibitors
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Published in Journal of virology (01.08.2015)
Published in Journal of virology (01.08.2015)
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The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase
Estoppey, David, Lee, Chia Min, Janoschke, Marco, Lee, Boon Heng, Wan, Kah Fei, Dong, Hongping, Mathys, Philippe, Filipuzzi, Ireos, Schuhmann, Tim, Riedl, Ralph, Aust, Thomas, Galuba, Olaf, McAllister, Gregory, Russ, Carsten, Spiess, Martin, Bouwmeester, Tewis, Bonamy, Ghislain M.C., Hoepfner, Dominic
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Published in Cell reports (Cambridge) (18.04.2017)
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Structure-Activity Relationship Studies of Phenanthridine-Based Bcl-X-L Inhibitors
Bernardo, Paul H., Wan, Kah-Fei, Sivaraman, Thirunavukkarasu, Xu, Jin, Moore, Felicity K., Hung, Alvin W., Mok, Henry Y. K., Yu, Victor C., Chai, Christina L. L.
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors
Zou, Bin, Chan, Wai Ling, Ding, Mei, Leong, Seh Yong, Nilar, Shahul, Seah, Peck Gee, Liu, Wei, Karuna, Ratna, Blasco, Francesca, Yip, Andy, Chao, Alex, Susila, Agatha, Dong, Hongping, Wang, Qing Yin, Xu, Hao Ying, Chan, Katherine, Wan, Kah Fei, Gu, Feng, Diagana, Thierry T, Wagner, Trixie, Dix, Ina, Shi, Pei-Yong, Smith, Paul W
Published in ACS medicinal chemistry letters (12.03.2015)
Published in ACS medicinal chemistry letters (12.03.2015)
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Structural Insights into the Design of Small Molecule Inhibitors That Selectively Antagonize Mcl-1
Bernardo, Paul H, Sivaraman, Thirunavukkarasu, Wan, Kah-Fei, Xu, Jin, Krishnamoorthy, Janarthanan, Song, Chun Meng, Tian, Liming, Chin, Jasmine S. F, Lim, Diane S. W, Mok, Henry Y. K, Yu, Victor C, Tong, Joo Chuan, Chai, Christina L. L
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign
Smith, Thomas M, Lim, Siew Pheng, Yue, Kimberley, Busby, Scott A, Arora, Rishi, Seh, Cheah Chen, Wright, S Kirk, Nutiu, Razvan, Niyomrattanakit, Pornwaratt, Wan, Kah Fei, Beer, David, Shi, Pei-Yong, Benson, Timothy E
Published in Journal of biomolecular screening (01.01.2015)
Published in Journal of biomolecular screening (01.01.2015)
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Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL
Wan, Kah Fei, Wang, Sifang, Brown, Christopher J., Yu, Victor C., Entzeroth, Michael, Lane, David P., Lee, May Ann
Published in Cell cycle (Georgetown, Tex.) (01.12.2009)
Published in Cell cycle (Georgetown, Tex.) (01.12.2009)
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Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl
Janssen, Christian O., Lim, Stephanie, Lo, Ee Peng, Wan, Kah Fei, Yu, Victor C., Lee, May Ann, Ng, Siew Bee, Everett, Martin J., Buss, Antony D., Lane, David P., Boyce, Rustum S.
Published in Bioorganic & medicinal chemistry (01.11.2008)
Published in Bioorganic & medicinal chemistry (01.11.2008)
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Structure−Activity Relationship Studies of Phenanthridine-Based Bcl-XL Inhibitors
Bernardo, Paul H, Wan, Kah-Fei, Sivaraman, Thirunavukkarasu, Xu, Jin, Moore, Felicity K, Hung, Alvin W, Mok, Henry Y. K, Yu, Victor C, Chai, Christina L. L
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
Moquin, Stephanie A, Simon, Oliver, Karuna, Ratna, Lakshminarayana, Suresh B, Yokokawa, Fumiaki, Wang, Feng, Saravanan, Chandra, Zhang, Jin, Day, Craig W, Chan, Katherine, Wang, Qing-Yin, Lu, Siyan, Dong, Hongping, Wan, Kah Fei, Lim, Siew Pheng, Liu, Wei, Seh, Cheah Chen, Chen, Yen-Liang, Xu, Haoying, Barkan, David T, Kounde, Cyrille S, Sim, Wei Lin Sandra, Wang, Gang, Yeo, Hui-Quan, Zou, Bin, Chan, Wai Ling, Ding, Mei, Song, Jae-Geun, Li, Min, Osborne, Colin, Blasco, Francesca, Sarko, Christopher, Beer, David, Bonamy, Ghislain M C, Sasseville, Vito G, Shi, Pei-Yong, Diagana, Thierry T, Yeung, Bryan K S, Gu, Feng
Published in Science translational medicine (03.02.2021)
Published in Science translational medicine (03.02.2021)
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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
Rao, Srinivasa P S, Gould, Matthew K, Noeske, Jonas, Saldivia, Manuel, Jumani, Rajiv S, Ng, Pearly S, René, Olivier, Chen, Yen-Liang, Kaiser, Marcel, Ritchie, Ryan, Francisco, Amanda Fortes, Johnson, Nila, Patra, Debjani, Cheung, Harry, Deniston, Colin, Schenk, Andreas D, Cortopassi, Wilian A, Schmidt, Remo S, Wiedemar, Natalie, Thomas, Bryanna, Palkar, Rima, Ghafar, Nahdiyah A, Manoharan, Vanessa, Luu, Catherine, Gable, Jonathan E, Wan, Kah Fei, Myburgh, Elmarie, Mottram, Jeremy C, Barnes, Whitney, Walker, John, Wartchow, Charles, Aziz, Natasha, Osborne, Colin, Wagner, Juergen, Sarko, Christopher, Kelly, John M, Manjunatha, Ujjini H, Mäser, Pascal, Jiricek, Jan, Lakshminarayana, Suresh B, Barrett, Michael P, Diagana, Thierry T
Published in Science (American Association for the Advancement of Science) (30.06.2023)
Published in Science (American Association for the Advancement of Science) (30.06.2023)
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Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit
Kounde, Cyrille S., Yeo, Hui-Quan, Wang, Qing-Yin, Wan, Kah Fei, Dong, Hongping, Karuna, Ratna, Dix, Ina, Wagner, Trixie, Zou, Bin, Simon, Oliver, Bonamy, Ghislain M.C., Yeung, Bryan K.S., Yokokawa, Fumiaki
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
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Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening
Niyomrattanakit, Pornwaratt, Wan, Kah Fei, Chung, Ka Yan, Abas, Siti Nurdiana, Seh, Cheah Chen, Dong, Hongping, Lim, Chin Chin, Chao, Alexander Theodore, Lee, Chang Bok, Nilar, Shahul, Lescar, Julien, Shi, Pei-Yong, Beer, David, Lim, Siew Pheng
Published in Antiviral research (01.07.2015)
Published in Antiviral research (01.07.2015)
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Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-X L
Wan, Kah Fei, Wang, Sifang, Brown, Christopher J., Yu, Victor C., Entzeroth, Michael, Lane, David P., Lee, May Ann
Published in Cell cycle (Georgetown, Tex.) (01.12.2009)
Published in Cell cycle (Georgetown, Tex.) (01.12.2009)
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