Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Meng, Wei, Ellsworth, Bruce A, Nirschl, Alexandra A, McCann, Peggy J, Patel, Manorama, Girotra, Ravindar N, Wu, Gang, Sher, Philip M, Morrison, Eamonn P, Biller, Scott A, Zahler, Robert, Deshpande, Prashant P, Pullockaran, Annie, Hagan, Deborah L, Morgan, Nathan, Taylor, Joseph R, Obermeier, Mary T, Humphreys, William G, Khanna, Ashish, Discenza, Lorell, Robertson, James G, Wang, Aiying, Han, Songping, Wetterau, John R, Janovitz, Evan B, Flint, Oliver P, Whaley, Jean M, Washburn, William N
Published in Journal of medicinal chemistry (13.03.2008)
Published in Journal of medicinal chemistry (13.03.2008)
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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5‑HT2C Receptor Agonists
Carpenter, Joseph, Wang, Ying, Wu, Gang, Feng, Jianxin, Ye, Xiang-Yang, Morales, Christian L, Broekema, Matthias, Rossi, Karen A, Miller, Keith J, Murphy, Brian J, Wu, Ginger, Malmstrom, Sarah E, Azzara, Anthony V, Sher, Philip M, Fevig, John M, Alt, Andrew, Bertekap, Robert L, Cullen, Mary Jane, Harper, Timothy M, Foster, Kimberly, Luk, Emily, Xiang, Qian, Grubb, Mary F, Robl, Jeffrey A, Wacker, Dean A
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT 2C Receptor Agonists
Carpenter, Joseph, Wang, Ying, Wu, Gang, Feng, Jianxin, Ye, Xiang-Yang, Morales, Christian L, Broekema, Matthias, Rossi, Karen A, Miller, Keith J, Murphy, Brian J, Wu, Ginger, Malmstrom, Sarah E, Azzara, Anthony V, Sher, Philip M, Fevig, John M, Alt, Andrew, Bertekap, Jr, Robert L, Cullen, Mary Jane, Harper, Timothy M, Foster, Kimberly, Luk, Emily, Xiang, Qian, Grubb, Mary F, Robl, Jeffrey A, Wacker, Dean A
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
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Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2
Ellsworth, Bruce A., Meng, Wei, Patel, Manorama, Girotra, Ravindar N., Wu, Gang, Sher, Philip M., Hagan, Deborah L., Obermeier, Mary T., Humphreys, William G., Robertson, James G., Wang, Aiying, Han, Songping, Waldron, Thomas L., Morgan, Nathan N., Whaley, Jean M., Washburn, William N.
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
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Reductions in log P Improved Protein Binding and Clearance Predictions Enabling the Prospective Design of Cannabinoid Receptor (CB1) Antagonists with Desired Pharmacokinetic Properties
Ellsworth, Bruce A, Sher, Philip M, Wu, Ximao, Wu, Gang, Sulsky, Richard B, Gu, Zhengxiang, Murugesan, Natesan, Zhu, Yeheng, Yu, Guixue, Sitkoff, Doree F, Carlson, Kenneth E, Kang, Liya, Yang, Yifan, Lee, Ning, Baska, Rose A, Keim, William J, Cullen, Mary Jane, Azzara, Anthony V, Zuvich, Eva, Thomas, Michael A, Rohrbach, Kenneth W, Devenny, James J, Godonis, Helen E, Harvey, Susan J, Murphy, Brian J, Everlof, Gerry G, Stetsko, Paul I, Gudmundsson, Olafur, Johnghar, Susan, Ranasinghe, Asoka, Behnia, Kamelia, Pelleymounter, Mary Ann, Ewing, William R
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces β3 binding selectivity
SHER, P. M, MATHUR, A, FISHER, L. G, WU, G, SKWISH, S, MICHEL, I. M, SEILER, S. M, DICKINSON, K. E. J
Published in Bioorganic & medicinal chemistry letters (01.06.1997)
Published in Bioorganic & medicinal chemistry letters (01.06.1997)
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Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists
Misra, Raj N, Brown, Baerbel R, Sher, Philip M, Patel, Manorama M, Hall, Steven E, Han, Wen Ching, Barrish, Joel C, Kocy, Octavian, Harris, Don N
Published in Journal of medicinal chemistry (01.05.1993)
Published in Journal of medicinal chemistry (01.05.1993)
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Addition of Benzylic and Allylic Organozinc and Grignard Reagents to Resin-Bound Imines To Provide α-Branched Secondary Amines Bearing a Wide Variety of Functional Groups. Utility in the Synthesis of β-3 Adrenergic Receptor Agonists
Wu, Gang, Cai, Zhen-Wei, Bednarz, Mark S, Kocy, Octavian R, Gavai, Ashvinikumar V, Godfrey, Jollie D, Washburn, William N, Poss, Michael A, Sher, Philip M
Published in Journal of combinatorial chemistry (01.01.2005)
Published in Journal of combinatorial chemistry (01.01.2005)
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Carboxyl-promoted enhancement of selectivity for the β 3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-β 3 binding selectivity
Sher, Philip M., Mathur, Arvind, Fisher, Liesl G., Wu, Gang, Skwish, Stephen, Michel, Inge M., Seiler, Steven M., Dickinson, Kenneth E.J.
Published in Bioorganic & medicinal chemistry letters (1997)
Published in Bioorganic & medicinal chemistry letters (1997)
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Thromboxane receptor antagonist BMS-180291: A new pre-clinical lead
Misra, Raj N., Brown, Baerbel R., Sher, Philip M., Patel, Manorama M., Hall, Steven E., Han, Wen-Ching, Barrish, Joel C., Floyd, David M., Sprague, Peter W., Morrison, Richard A., Ridgewell, Richard E., White, Ronald E., DiDonato, Gerald C., Harris, Don N., Hedberg, Anders, Schumacher, William A., Webb, Maria L., Ogletree, Martin L.
Published in Bioorganic & medicinal chemistry letters (1992)
Published in Bioorganic & medicinal chemistry letters (1992)
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Interphenylene 7-oxabicyclo[2.2.1]heptanes. SQ33,961: a new potent, long-acting thromboxane antagonist
Misra, Raj N., Brown, Baerbel R., Sher, Philip M., Patel, Manorama M., Goldenberg, Harold J., Michel, Inge M., Harris, Don N.
Published in Bioorganic & medicinal chemistry letters (1991)
Published in Bioorganic & medicinal chemistry letters (1991)
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