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Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides
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Published in Nucleic acids research (06.09.2016)
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Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
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Published in Nature biotechnology (01.06.2019)
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Published in Nucleic acids research (20.09.2021)
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2'-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF
Shen, Wen, Liang, Xue-Hai, Sun, Hong, Crooke, Stanley T
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Insights into innate immune activation via PS-ASO–protein–TLR9 interactions
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Published in Nucleic acids research (12.08.2022)
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Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides
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Published in Nucleic acids research (19.05.2017)
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Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins
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Published in Journal of the American Chemical Society (22.04.2020)
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mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway
Liang, Xue-Hai, Nichols, Joshua G, Hsu, Chih-Wei, Vickers, Timothy A, Crooke, Stanley T
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Published in Cell (31.08.2012)
Published in Cell (31.08.2012)
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