Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals
Rucktooa, Prakash, Cheng, Robert K. Y., Segala, Elena, Geng, Tian, Errey, James C., Brown, Giles A., Cooke, Robert M., Marshall, Fiona H., Doré, Andrew S.
Published in Scientific reports (08.01.2018)
Published in Scientific reports (08.01.2018)
Get full text
Journal Article
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.
Published in Nature communications (16.09.2021)
Published in Nature communications (16.09.2021)
Get full text
Journal Article
Structural insight into allosteric modulation of protease-activated receptor 2
Cheng, Robert K. Y., Fiez-Vandal, Cédric, Schlenker, Oliver, Edman, Karl, Aggeler, Birte, Brown, Dean G., Brown, Giles A., Cooke, Robert M., Dumelin, Christoph E., Doré, Andrew S., Geschwindner, Stefan, Grebner, Christoph, Hermansson, Nils-Olov, Jazayeri, Ali, Johansson, Patrik, Leong, Louis, Prihandoko, Rudi, Rappas, Mathieu, Soutter, Holly, Snijder, Arjan, Sundström, Linda, Tehan, Benjamin, Thornton, Peter, Troast, Dawn, Wiggin, Giselle, Zhukov, Andrei, Marshall, Fiona H., Dekker, Niek
Published in Nature (London) (04.05.2017)
Published in Nature (London) (04.05.2017)
Get full text
Journal Article
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease
Brown, Alastair J H, Bradley, Sophie J, Marshall, Fiona H, Brown, Giles A, Bennett, Kirstie A, Brown, Jason, Cansfield, Julie E, Cross, David M, de Graaf, Chris, Hudson, Brian D, Dwomoh, Louis, Dias, João M, Errey, James C, Hurrell, Edward, Liptrot, Jan, Mattedi, Giulio, Molloy, Colin, Nathan, Pradeep J, Okrasa, Krzysztof, Osborne, Greg, Patel, Jayesh C, Pickworth, Mark, Robertson, Nathan, Shahabi, Shahram, Bundgaard, Christoffer, Phillips, Keith, Broad, Lisa M, Goonawardena, Anushka V, Morairty, Stephen R, Browning, Michael, Perini, Francesca, Dawson, Gerard R, Deakin, John F W, Smith, Robert T, Sexton, Patrick M, Warneck, Julie, Vinson, Mary, Tasker, Tim, Tehan, Benjamin G, Teobald, Barry, Christopoulos, Arthur, Langmead, Christopher J, Jazayeri, Ali, Cooke, Robert M, Rucktooa, Prakash, Congreve, Miles S, Weir, Malcolm, Tobin, Andrew B
Published in Cell (24.11.2021)
Published in Cell (24.11.2021)
Get full text
Journal Article
Targeting adenosine A 2A receptor antagonism for treatment of cancer
Congreve, Miles, Brown, Giles A, Borodovsky, Alexandra, Lamb, Michelle L
Published in Expert opinion on drug discovery (02.11.2018)
Published in Expert opinion on drug discovery (02.11.2018)
Get more information
Journal Article
Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.
Published in Nature communications (08.12.2021)
Published in Nature communications (08.12.2021)
Get full text
Journal Article
Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity
Borodovsky, Alexandra, Barbon, Christine M, Wang, Yanjun, Ye, Minwei, Prickett, Laura, Chandra, Dinesh, Shaw, Joseph, Deng, Nanhua, Sachsenmeier, Kris, Clarke, James D, Bolan Linghu, Brown, Giles A, Brown, James, Congreve, Miles, Cheng, Robert KY, Dore, Andrew S, Hurrell, Edward, Shao, Wenlin, Woessner, Richard, Reimer, Corinne, Drew, Lisa, Fawell, Stephen, Schuller, Alwin G, Mele, Deanna A
Published in Journal for immunotherapy of cancer (01.07.2020)
Published in Journal for immunotherapy of cancer (01.07.2020)
Get full text
Journal Article
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M 1 -receptor partial agonist for the treatment of dementias
Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P, Klaassen, Erica S, Prins, Samantha, van der Doef, Thalia F, Brown, Giles A, Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H, Cross, David M, Groeneveld, Geert Jan, Nathan, Pradeep J
Published in British journal of clinical pharmacology (01.07.2021)
Published in British journal of clinical pharmacology (01.07.2021)
Get full text
Journal Article
First‐in‐man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1‐receptor partial agonist for the treatment of dementias
Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Prins, Samantha, Doef, Thalia F., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Published in British journal of clinical pharmacology (01.07.2021)
Published in British journal of clinical pharmacology (01.07.2021)
Get full text
Journal Article
Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound β1-Adrenergic Receptor
Sato, Tomomi, Baker, Jillian, Warne, Tony, Brown, Giles A, Leslie, Andrew G W, Congreve, Miles, Tate, Christopher G
Published in Molecular pharmacology (01.12.2015)
Published in Molecular pharmacology (01.12.2015)
Get full text
Journal Article
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1‐acetylcholine receptor agonist: A randomized cross‐over trial
Bakker, Charlotte, Prins, Samantha, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Stevens, Jasper, Cross, David M., Tasker, Tim, Nathan, Pradeep J., Groeneveld, Geert Jan
Published in British journal of clinical pharmacology (01.11.2021)
Published in British journal of clinical pharmacology (01.11.2021)
Get full text
Journal Article
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M 1 -acetylcholine receptor agonist: A randomized cross-over trial
Bakker, Charlotte, Prins, Samantha, Liptrot, Jan, Hart, Ellen P, Klaassen, Erica S, Brown, Giles A, Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H, Stevens, Jasper, Cross, David M, Tasker, Tim, Nathan, Pradeep J, Groeneveld, Geert Jan
Published in British journal of clinical pharmacology (01.11.2021)
Published in British journal of clinical pharmacology (01.11.2021)
Get full text
Journal Article
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study
Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Doll, Robert Jan, Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Published in Alzheimer's research & therapy (21.04.2021)
Published in Alzheimer's research & therapy (21.04.2021)
Get full text
Journal Article
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein–Ligand Complexes
Cansfield, Andrew D, Ator, Mark A, Banerjee, Joydeep, Bestwick, Michael, Bortolato, Andrea, Brown, Giles A, Brown, Jason, Butkovic, Kristina, Cansfield, Julie E, Christopher, John A, Congreve, Miles, Cseke, Gabriella, Deflorian, Francesca, Dugan, Benjamin, Hunjadi, Martina Petrovic, Hutinec, Antun, Inturi, Trinadh Kumar, Landek, Goran, Mason, Jonathan, O’Brien, Alistair, Ott, Gregory R, Rupcic, Renata, Saxty, Gordon, Southall, Stacey M, Zadravec, Rahela, Watson, Stephen P
Published in ACS chemical neuroscience (16.03.2022)
Published in ACS chemical neuroscience (16.03.2022)
Get full text
Journal Article
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design
O'Brien, Alistair, Andrews, Stephen P., Baig, Asma H., Bortolato, Andrea, Brown, Alastair J.H., Brown, Giles A., Brown, Sue H., Christopher, John A., Congreve, Miles, Cooke, Robert M., De Graaf, Chris, Errey, James C., Fieldhouse, Charlotte, Jazayeri, Ali, Marshall, Fiona H., Mason, Jonathan S., Mobarec, Juan Carlos, Okrasa, Krzysztof, Steele, Kelly N., Southall, Stacey M., Teobald, Iryna, Watson, Steve P., Weir, Malcolm
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Get full text
Journal Article
Inferring Negative Molecular Biomarker Data at Scale
McBratney, Ashleigh E, Holmes, Benjamin A, Brown, Giles S, Warrier, Raghu, Berry, Anna B
Published in JCO clinical cancer informatics (01.03.2023)
Published in JCO clinical cancer informatics (01.03.2023)
Get more information
Journal Article
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M 1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study
Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P, Klaassen, Erica S, Doll, Robert Jan, Brown, Giles A, Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H, Cross, David M, Groeneveld, Geert Jan, Nathan, Pradeep J
Published in Alzheimer's research & therapy (21.04.2021)
Published in Alzheimer's research & therapy (21.04.2021)
Get full text
Journal Article