Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain
Stachel, Shawn J, Sanders, John M, Henze, Darrell A, Rudd, Mike T, Su, Hua-Poo, Li, Yiwei, Nanda, Kausik K, Egbertson, Melissa S, Manley, Peter J, Jones, Kristen L. G, Brnardic, Edward J, Green, Ahren, Grobler, Jay A, Hanney, Barbara, Leitl, Michael, Lai, Ming-Tain, Munshi, Vandna, Murphy, Dennis, Rickert, Keith, Riley, Daniel, Krasowska-Zoladek, Alicja, Daley, Christopher, Zuck, Paul, Kane, Stephanie A, Bilodeau, Mark T
Published in Journal of medicinal chemistry (10.07.2014)
Published in Journal of medicinal chemistry (10.07.2014)
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MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate
Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy
Trotter, B. Wesley, Nanda, Kausik K., Burgey, Christopher S., Potteiger, Craig M., Deng, James Z., Green, Ahren I., Hartnett, John C., Kett, Nathan R., Wu, Zhicai, Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Development of the Copper-Catalyzed Olefin Aziridination Reaction
Evans, David A, Bilodeau, Mark T, Faul, Margaret M
Published in Journal of the American Chemical Society (01.04.1994)
Published in Journal of the American Chemical Society (01.04.1994)
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Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo
White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
Perino, Samantha, Moreau, Benoit, Freda, Jessica, Cirello, Amanda, White, Brian H., Quinn, James M., Kriksciukaite, Kristina, Someshwar, Ashwajith, Romagnoli, Janel, Robinson, Megan, Movassaghian, Sara, Cipriani, Tyler, Wooster, Richard, Bilodeau, Mark T., Whalen, Kerry A.
Published in Molecular cancer therapeutics (01.08.2020)
Published in Molecular cancer therapeutics (01.08.2020)
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Structural characterization of nonactive site, TrkA-selective kinase inhibitors
Su, Hua-Poo, Rickert, Keith, Burlein, Christine, Narayan, Kartik, Bukhtiyarova, Marina, Hurzy, Danielle M., Stump, Craig A., Zhang, Xufang, Reid, John, Krasowska-Zoladek, Alicja, Tummala, Srivanya, Shipman, Jennifer M., Kornienko, Maria, Lemaire, Peter A., Krosky, Daniel, Heller, Amanda, Achab, Abdelghani, Chamberlin, Chad, Saradjian, Peter, Sauvagnat, Berengere, Yang, Xianshu, Ziebell, Michael R., Nickbarg, Elliott, Sanders, John M., Bilodeau, Mark T., Carroll, Steven S., Lumb, Kevin J., Soisson, Stephen M., Henze, Darrell A., Cooke, Andrew J.
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
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Identification and in Vivo Evaluation of Liver X Receptor β‑Selective Agonists for the Potential Treatment of Alzheimer’s Disease
Stachel, Shawn J, Zerbinatti, Celina, Rudd, Michael T, Cosden, Mali, Suon, Sokreine, Nanda, Kausik K, Wessner, Keith, DiMuzio, Jillian, Maxwell, Jill, Wu, Zhenhua, Uslaner, Jason M, Michener, Maria S, Szczerba, Peter, Brnardic, Edward, Rada, Vanessa, Kim, Yuntae, Meissner, Robert, Wuelfing, Peter, Yuan, Yang, Ballard, Jeanine, Holahan, Marie, Klein, Daniel J, Lu, Jun, Fradera, Xavier, Parthasarathy, Gopal, Uebele, Victor N, Chen, Zhongguo, Li, Yingjie, Li, Jian, Cooke, Andrew J, Bennett, D. Jonathan, Bilodeau, Mark T, Renger, John
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Journal Article
Copper-catalyzed aziridination of olefins by (N-(p-toluenesulfonyl)imino)phenyliodinane
Evans, David A, Faul, Margaret M, Bilodeau, Mark T
Published in Journal of organic chemistry (01.11.1991)
Published in Journal of organic chemistry (01.11.1991)
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Simple Method Provides Resolution of Albumin, Lipoprotein, Free Fraction, and Chylomicron To Enhance the Utility of Protein Binding Assays
Brockman, Adam H, Oller, Haley R, Moreau, Benoît, Kriksciukaite, Kristina, Bilodeau, Mark T
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
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MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate
Beshore, Douglas C, N Di Marco, Christina, Chang, Ronald K, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Fuerst, Joy, Hartman, George D, Bilodeau, Mark T, Ray, William J, Kuduk, Scott D
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Journal Article
Discovery of a Selective Allosteric M1 Receptor Modulator with Suitable Development Properties Based on a Quinolizidinone Carboxylic Acid Scaffold
Kuduk, Scott D, Chang, Ronald K, Di Marco, Christina N, Pitts, Daniel R, Greshock, Thomas J, Ma, Lei, Wittmann, Marion, Seager, Matthew A, Koeplinger, Kenneth A, Thompson, Charles D, Hartman, George D, Bilodeau, Mark T, Ray, William J
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
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Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors
Greshock, Thomas J., Sanders, John M., Drolet, Robert E., Rajapakse, Hemaka A., Chang, Ronald K., Kim, Boyoung, Rada, Vanessa L., Tiscia, Heather E., Su, Hua, Lai, Ming-Tain, Sur, Sylvie M., Sanchez, Rosa I., Bilodeau, Mark T., Renger, John J., Kern, Jonathan T., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
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