Biomedical Applications of Acridines : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases.

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, i...

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Bibliographic Details
Main Author Ježek, Jan
Other Authors Hlaváček, Jan, Šebestík, Jaroslav
Format Electronic eBook
LanguageEnglish
Published Cham : Springer International Publishing, 2017.
SeriesProgress in drug research ; v. 72.
Subjects
Acridine.
elektronické knihy
electronic books
Online AccessPlný text

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Table of Contents:
  • Acknowledgements; Contents; Acronyms; 1 Introduction; References; 2 Nomenclature; References; 3 Syntheses; 3.1 Syntheses of Acridine Ring and Its Precursors; 3.2 Acridine-Peptide Conjugates; 3.3 Acridines as Catalysts; References; 4 Interactions of Acridines with Nucleic Acids; 4.1 DNA; 4.2 DNA Quadruplexes; 4.3 RNA; 4.4 PNA; 4.5 Acridine Metal Complexes; 4.6 Structural Aspects of Nucleic Acid Binding; References; 5 Interactions with Proteins; 5.1 Interactions with Nucleic Acids Processing Proteins; 5.1.1 Topoisomerases; 5.1.2 Transcription Factors; 5.1.3 RecA Protein; 5.1.4 Telomerase.
  • 5.2 Interactions with Other Proteins5.3 Structural Aspects of Acridine Interactions with Proteins; References; 6 Applications for Treatment of Neurodegenerative Diseases; 6.1 Alzheimer's Disease; 6.1.1 Multitargeted Strategy in AD; 6.2 Parkinson's Disease; 6.3 Prion Diseases; 6.4 Other Neurodegenerative Diseases; References; 7 Some Application of Selective Toxicities of Acridines; 7.1 Antiparasitic Drug; 7.2 Cancer Treatment; 7.3 Antibacterial Drugs; 7.4 Antiviral Drugs; References; 8 Pharmacokinetics and Metabolism of Acridine Drugs; References; 9 Acridine on Dendrimeric Carriers.
  • 9.1 Application for Drug and Gene DeliveryReferences; 10 Acridines Used for Staining; References; 11 Miscellaneous; References; 12 Conclusions and Outlook; Index.

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